{"id":"W2001356550","doi":"10.1128/jvi.74.15.6790-6799.2000","title":"The Human Factors YY1 and LSF Repress the Human Immunodeficiency Virus Type 1 Long Terminal Repeat via Recruitment of Histone Deacetylase 1","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":346,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Medical Research Council Canada; National Institute of General Medical Sciences; Medical Research Council; Dana-Farber Cancer Institute; Infectious Diseases Society of America","keywords":"Biology; Repressor; YY1; Trichostatin A; Psychological repression; Long terminal repeat; Histone deacetylase; HDAC1; HIV Long Terminal Repeat; Transcription factor; Virology; Molecular biology; Promoter; Histone; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000707466,0.0001660697,0.0003602096,0.00008728209,0.0007089869,0.00001540411,0.0003940448,0.0001571565,0.0007889182],"category_scores_gemma":[0.00005712133,0.00008453982,0.0001339369,0.00007850247,0.0009018229,0.00006303738,0.00008149153,0.0005360955,0.00005876881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007519619,"about_ca_system_score_gemma":0.00005800825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002761018,"about_ca_topic_score_gemma":0.0001196718,"domain_scores_codex":[0.9981997,0.0005661232,0.0005907564,0.0001812605,0.00008765451,0.0003744906],"domain_scores_gemma":[0.99879,0.0002809746,0.0003779856,0.0004084879,0.0001018154,0.00004074089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001069243,0.0006824059,0.01434402,0.0000121915,0.0007340494,0.0002226347,0.001554589,0.00001413043,0.9418166,0.0002099075,0.001621277,0.03771894],"study_design_scores_gemma":[0.00669768,0.01219667,0.6214907,0.00008312901,0.0005756416,0.004482905,0.0007393071,0.00000298671,0.2478011,0.001096952,0.1044206,0.0004124551],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836023,0.01495422,0.000006029674,0.0003756675,0.0002075427,0.0002344565,0.00001213966,0.000006250001,0.0006014244],"genre_scores_gemma":[0.9958049,0.001361478,0.000007307458,0.00004354087,0.00002928103,0.000008511037,0.00001351566,0.00001110836,0.002720339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6940155,"threshold_uncertainty_score":0.8638101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0410924279099917,"score_gpt":0.3518681179079235,"score_spread":0.3107756899979318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}