{"id":"W2001356550","doi":"10.1128/jvi.74.15.6790-6799.2000","title":"The Human Factors YY1 and LSF Repress the Human Immunodeficiency Virus Type 1 Long Terminal Repeat via Recruitment of Histone Deacetylase 1","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":346,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Medical Research Council Canada; National Institute of General Medical Sciences; Medical Research Council; Dana-Farber Cancer Institute; Infectious Diseases Society of America","keywords":"Biology; Repressor; YY1; Trichostatin A; Psychological repression; Long terminal repeat; Histone deacetylase; HDAC1; HIV Long Terminal Repeat; Transcription factor; Virology; Molecular biology; Promoter; Histone; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001381051,0.0003655109,0.0001250162,0.0001610973,0.0001602558,0.000368972,0.0001658118,0.0001450242,0.002060708],"category_scores_gemma":[0.0002085931,0.0001248989,0.0001595034,0.00007863066,0.0002367804,0.0001499307,0.0002675445,0.0003030889,0.0005377582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004992087,"about_ca_system_score_gemma":0.0002912026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007489948,"about_ca_topic_score_gemma":0.001203579,"domain_scores_codex":[0.9999002,0.00001382301,0.00000655495,0.00002206318,0.0000291927,0.00002810917],"domain_scores_gemma":[0.999921,0.00001092067,0.00002672832,0.000007773392,0.000007935566,0.0000255952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395711,0.00001318175,0.0009161347,0.00003802549,0.00000810783,0.00004552492,0.00001824337,0.00006486898,0.9940439,0.0002889351,0.0001666428,0.004256925],"study_design_scores_gemma":[0.00004474297,0.0003178453,0.02325284,0.00001794727,0.00002708555,0.0005086423,0.00006144495,0.001750264,0.9503322,0.0003453753,0.02333242,0.00000911772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782898,0.01224501,0.00464303,0.0002564589,0.00009181227,0.00003165243,0.0006061402,0.0001711361,0.003665098],"genre_scores_gemma":[0.9903945,0.001841862,0.001545642,0.00007124433,0.00003456788,0.00003025043,0.0007442643,0.00002103108,0.005316702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002060708,"threshold_uncertainty_score":0.006893754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0410924279099917,"score_gpt":0.3518681179079235,"score_spread":0.3107756899979318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}