{"id":"W2001364008","doi":"10.1371/journal.pone.0005031","title":"Autocatalytic Activation of the Furin Zymogen Requires Removal of the Emerging Enzyme's N-Terminus from the Active Site","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; National Center for Research Resources; Susan G. Komen for the Cure","keywords":"Furin; Zymogen; Cleavage (geology); Enzyme; Mutant; Chemistry; Biochemistry; Active site; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001230734,0.000192716,0.00009622107,0.00005594678,0.00009114724,0.0002202877,0.0001352614,0.0001558972,0.0006230234],"category_scores_gemma":[0.0000964499,0.0000770196,0.0001718261,0.0000502672,0.0001879936,0.0001563663,0.0001274784,0.0004313006,0.0002521209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002574025,"about_ca_system_score_gemma":0.0002757251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000488341,"about_ca_topic_score_gemma":0.000708067,"domain_scores_codex":[0.9999297,0.000007590268,0.000007436881,0.00001666309,0.00002103546,0.0000177607],"domain_scores_gemma":[0.9998751,0.0000274208,0.00004794908,0.000017021,0.00001215684,0.0000204434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003537281,0.000009859042,0.000220878,0.000008948246,0.000001034196,0.00004294969,0.000007378013,0.00003014845,0.9992688,0.0001081985,0.000004988678,0.0002614221],"study_design_scores_gemma":[0.000004399607,0.00005507018,0.002114801,0.000002197429,0.000002861179,0.0002298682,0.0000151823,0.0004547169,0.9965097,0.00003637432,0.0005731225,0.00000161298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968971,0.0001176917,0.002511006,0.00002057338,0.000004073101,0.000007034594,0.00008420242,0.000009572588,0.0003487537],"genre_scores_gemma":[0.9954109,0.0001383325,0.003262192,0.00001582987,0.000002491083,0.000009320315,0.0002473789,0.000008449693,0.0009051462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006230234,"threshold_uncertainty_score":0.002084196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02805102636524188,"score_gpt":0.2483410798309642,"score_spread":0.2202900534657224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}