{"id":"W2001376867","doi":"10.1038/sj.onc.1210739","title":"Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma","year":2007,"lang":"en","type":"article","venue":"Oncogene","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôtel-Dieu de Montréal; Women's College Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Missense mutation; Germline; Genetics; Germline mutation; BRCA2 Protein; Mutation; Cancer research; Population; Nonsense mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003018379,0.00007512454,0.00009161101,0.00002010204,0.00009793133,0.000007710614,0.00008135063,0.00005836344,0.0000212684],"category_scores_gemma":[0.00003197308,0.00005461749,0.00005954496,0.0000455405,0.0001270977,0.000001544143,0.00005305706,0.00004302788,0.000002778617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005417184,"about_ca_system_score_gemma":0.00003807087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001680201,"about_ca_topic_score_gemma":0.00009616921,"domain_scores_codex":[0.9994704,0.00004256724,0.0001825775,0.0001231982,0.00005995068,0.0001213167],"domain_scores_gemma":[0.9995835,0.00004111399,0.00009854437,0.000182476,0.00005720699,0.00003719604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006769574,0.0003196163,0.2197111,0.00008998235,0.000137352,0.0000201599,0.002356088,0.0006938408,0.7662292,0.004203364,0.0006100878,0.004952279],"study_design_scores_gemma":[0.003352803,0.0002346098,0.09821048,0.000001654696,0.0001389478,0.00005017607,0.000715457,0.0001155613,0.892912,0.0004447399,0.003655487,0.0001680733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937416,0.001896756,0.001347878,0.00005075404,0.00005496608,0.00009957367,0.00006350106,0.000003153679,0.002741769],"genre_scores_gemma":[0.9979054,0.00006573817,0.0008226752,0.00005697288,0.000154182,0.000005233345,0.00005804294,0.00000869724,0.0009230414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1266829,"threshold_uncertainty_score":0.2227236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00435689816091558,"score_gpt":0.2090841206144888,"score_spread":0.2047272224535732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}