{"id":"W2001404419","doi":"10.1074/jbc.m300823200","title":"Zinc-binding Sites in the N Terminus of Mycoplasma arthritidis-derived Mitogen Permit the Dimer Formation Required for High Affinity Binding to HLA-DR and for T Cell Activation","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research; Arthritis Society","keywords":"Zinc; Major histocompatibility complex; Dimer; MHC class II; Biology; Subfamily; Histidine; Superantigen; Chemistry; Biochemistry; T cell; Amino acid; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001615908,0.0002797356,0.0002947429,0.0001074212,0.0002067491,0.0001775295,0.0001998261,0.0002851727,0.001371465],"category_scores_gemma":[0.0003037638,0.0001399569,0.0002230379,0.00009746869,0.0002347658,0.0002232469,0.0002410475,0.0003701039,0.000772825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002437929,"about_ca_system_score_gemma":0.0002191224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002540428,"about_ca_topic_score_gemma":0.0005911151,"domain_scores_codex":[0.9998475,0.0000330023,0.00001437409,0.00002988563,0.000042221,0.00003293184],"domain_scores_gemma":[0.9997903,0.0000477275,0.00005936997,0.00002967099,0.00001957157,0.00005346124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001303342,0.00001757638,0.0002077319,0.00003215557,0.000002483493,0.00009401856,0.000007493214,0.00003668564,0.9985734,0.0001105292,0.00001829873,0.0007692196],"study_design_scores_gemma":[0.0000465525,0.000350998,0.007980218,0.00001328485,0.00001701608,0.001445002,0.00003300116,0.0007022874,0.9858513,0.0003157113,0.003237121,0.000007501151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99434,0.00101383,0.003313875,0.000054159,0.00001854085,0.00002823846,0.0001714605,0.00005009285,0.001009796],"genre_scores_gemma":[0.9931131,0.0003366327,0.004512184,0.0000447253,0.000009417945,0.0000207321,0.0006300308,0.00001568231,0.001317429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001371465,"threshold_uncertainty_score":0.004588008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05191221894097679,"score_gpt":0.2947344591232091,"score_spread":0.2428222401822323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}