{"id":"W2001468172","doi":"10.1021/ja305213z","title":"Kinetic Stability of the Streptavidin–Biotin Interaction Enhanced in the Gas Phase","year":2012,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Alberta Glycomics Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Chemistry; Streptavidin; Ion; Protonation; Kinetic energy; Crystallography; Electrospray ionization; Phase (matter); Analytical Chemistry (journal); Biotin; Chromatography; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004033335,0.00008949145,0.0001653578,0.000004123017,0.00004968548,0.000005357297,0.000355386,0.00006239831,0.000007123382],"category_scores_gemma":[0.0001805587,0.00003836996,0.0004170694,0.000174382,0.0004552482,0.000004146306,0.0001301121,0.0003891337,2.959412e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003624555,"about_ca_system_score_gemma":0.00002892611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001718039,"about_ca_topic_score_gemma":0.000001773221,"domain_scores_codex":[0.9991518,0.0001452897,0.0002894611,0.00007887574,0.0001739625,0.0001606622],"domain_scores_gemma":[0.9991117,0.00005492749,0.0005083337,0.0002310338,0.00006451731,0.00002945508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006596737,0.0002650908,0.005327119,0.00000751573,0.00007290915,4.132899e-8,0.000745517,0.000003362984,0.9903805,0.000002258327,0.00190603,0.001223706],"study_design_scores_gemma":[0.000386221,0.0001018332,0.006689053,0.00002379937,0.00004442758,0.00001527693,0.002679884,0.000008447016,0.9880978,0.00001342637,0.001888008,0.00005183176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997229,0.0004368355,0.0000335623,0.001860023,0.0001945511,0.00007583792,0.000003385224,9.760724e-7,0.0001657808],"genre_scores_gemma":[0.99883,0.0003075578,0.0001538628,0.0004715277,0.0002202783,0.000001147649,6.774075e-7,0.000005133981,0.000009840644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00228269,"threshold_uncertainty_score":0.1690614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119239473051505,"score_gpt":0.2894437376240859,"score_spread":0.2775197903189354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}