{"id":"W2001476650","doi":"10.1016/j.bmcl.2006.10.014","title":"Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Sphingosine; Receptor; Sphingosine-1-phosphate; Sphingosine kinase; Biochemistry; Enantiomer; Phosphorylation; Kinase; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591175,0.0002877673,0.0003053088,0.0001662722,0.0001764197,0.0002866526,0.0004195303,0.0003390648,0.00291679],"category_scores_gemma":[0.0001603842,0.0001427052,0.0001235985,0.000203764,0.0002268828,0.0004038466,0.000266595,0.0005806338,0.000441964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000368828,"about_ca_system_score_gemma":0.000131534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000460119,"about_ca_topic_score_gemma":0.0008560071,"domain_scores_codex":[0.9999125,0.00002161163,0.000004125234,0.00001537885,0.00001651944,0.00002978292],"domain_scores_gemma":[0.9999477,0.00001647323,0.00001318543,0.000006637177,0.00000406594,0.00001193088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001131359,0.00007847607,0.0001102836,0.000132505,0.00002207334,0.000305525,0.00008614301,0.002480657,0.9830611,0.003002146,0.0003897489,0.009200048],"study_design_scores_gemma":[0.000199219,0.001188037,0.0005366785,0.0000136043,0.00003585346,0.0002340498,0.00003521956,0.001825186,0.9847736,0.0004965523,0.01063738,0.00002466563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811024,0.005688957,0.005581416,0.0002126301,0.00008819379,0.00006693383,0.000365702,0.00007696399,0.006816775],"genre_scores_gemma":[0.9915036,0.002517197,0.002434041,0.00008632094,0.00002390799,0.00004856609,0.0002557647,0.00001897942,0.003111618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00291679,"threshold_uncertainty_score":0.009757638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004517545076678728,"score_gpt":0.2071955048673,"score_spread":0.2026779597906213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}