{"id":"W2001476678","doi":"10.1016/j.vaccine.2004.10.034","title":"Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an αβ T cell- and interferon gamma- dependent mechanism","year":2004,"lang":"en","type":"article","venue":"Vaccine","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Defence Research and Development Canada","keywords":"Francisella tularensis; Virulence; Microbiology; Pathogen; Tularemia; Attenuated vaccine; Biology; Virology; Immunity; Francisella; Immunization; Immune system; Vaccination; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266504,0.0007532548,0.0004573149,0.0003345716,0.0001974424,0.0003253847,0.0002600109,0.0008202798,0.0009561053],"category_scores_gemma":[0.0002426554,0.0002255855,0.0002771193,0.00009392629,0.0004300579,0.0004164014,0.0002044153,0.001436387,0.0004406747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280305,"about_ca_system_score_gemma":0.0003625121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003950939,"about_ca_topic_score_gemma":0.0004679715,"domain_scores_codex":[0.9997669,0.00002937641,0.00001361097,0.00004383731,0.00004613658,0.0001002243],"domain_scores_gemma":[0.999651,0.00005951788,0.0001070405,0.00005706691,0.00003713213,0.00008823183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004967385,0.0002456848,0.0002972556,0.00003085334,0.000006183964,0.0000407636,0.00001772593,0.00006035154,0.9966775,0.00006999885,0.00006317962,0.001993682],"study_design_scores_gemma":[0.0001667606,0.003255788,0.008605422,0.00002344696,0.00003950794,0.0003273195,0.00005258703,0.0008987096,0.9853537,0.0001786835,0.001087508,0.00001059039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962946,0.001032347,0.001240835,0.00013553,0.00007759407,0.00003251293,0.00009563796,0.0001215611,0.0009693748],"genre_scores_gemma":[0.9961317,0.0005745794,0.0008013539,0.0001123235,0.000044219,0.00003393785,0.0002971985,0.00001880998,0.001985895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009561053,"threshold_uncertainty_score":0.003198504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008631829040308622,"score_gpt":0.2072188375002732,"score_spread":0.1985870084599646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}