{"id":"W2001476678","doi":"10.1016/j.vaccine.2004.10.034","title":"Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an αβ T cell- and interferon gamma- dependent mechanism","year":2004,"lang":"en","type":"article","venue":"Vaccine","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Defence Research and Development Canada","keywords":"Francisella tularensis; Virulence; Microbiology; Pathogen; Tularemia; Attenuated vaccine; Biology; Virology; Immunity; Francisella; Immunization; Immune system; Vaccination; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003581647,0.0002911893,0.0003086322,0.00003743845,0.0001204479,0.00003051996,0.0003779498,0.0001794396,0.00001728167],"category_scores_gemma":[0.00002902653,0.0001680154,0.000051723,0.0001666025,0.00004979589,0.00001417481,0.0001563866,0.0002233759,0.000001033107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004033511,"about_ca_system_score_gemma":0.0001646729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001892131,"about_ca_topic_score_gemma":0.001224112,"domain_scores_codex":[0.9983779,0.0001683511,0.0003288908,0.0004347126,0.0003606463,0.0003295025],"domain_scores_gemma":[0.9986562,0.00001476251,0.0002535025,0.0005898172,0.0003782999,0.0001073896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001552347,0.0002412728,0.00003188237,0.0001190282,0.00009371997,0.000005703844,0.0007647473,0.0001985689,0.995848,0.00003844257,0.000009225701,0.001097032],"study_design_scores_gemma":[0.002879643,0.0035681,0.0004062256,0.00009643259,0.00005095734,0.00001875387,0.0005620533,0.00007369451,0.9920664,0.00001603703,0.00004390563,0.0002177819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994749,0.000859689,0.002172751,0.0006531798,0.00004487667,0.001149869,0.0003360297,0.000009480063,0.0000251722],"genre_scores_gemma":[0.9984397,0.0008244138,0.000265161,0.000113906,0.00006637529,0.00004833697,0.0001613315,0.00004866945,0.00003214683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003781614,"threshold_uncertainty_score":0.6851471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008631829040308622,"score_gpt":0.2072188375002732,"score_spread":0.1985870084599646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}