{"id":"W2001487688","doi":"10.1172/jci43048","title":"Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Child and Family Research Institute; Children's Hospital of Philadelphia","keywords":"NOD mice; FOXP3; CCL22; Immunology; IL-2 receptor; Pancreatic islets; Chemokine; Immune system; Islet; Autoimmunity; Nod; CD8; Biology; Medicine; T cell; Diabetes mellitus; Endocrinology; CXCL10","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00138383,0.00009425233,0.0002782171,0.00003277641,0.00003260257,0.000009239657,0.0001882535,0.0001287201,0.00002702504],"category_scores_gemma":[0.001519662,0.00006456702,0.0002021283,0.0001193816,0.00009330394,0.000009899981,0.00004011718,0.0001333165,0.000005937362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009374339,"about_ca_system_score_gemma":0.00009879307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009165765,"about_ca_topic_score_gemma":0.000005425646,"domain_scores_codex":[0.9983212,0.0002662288,0.0009779789,0.0001184218,0.0001805987,0.0001355585],"domain_scores_gemma":[0.9984914,0.00008909375,0.0009487495,0.0001648162,0.0001952591,0.0001106666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003634992,0.001524374,0.2364024,0.00006900717,0.00122817,0.000001821404,0.0006220579,0.0001072472,0.624992,0.00009976103,0.0700713,0.06451838],"study_design_scores_gemma":[0.004510159,0.00853617,0.4641365,0.0004921162,0.0005439515,0.000002431308,0.0003583666,0.0003812808,0.4558549,0.004121344,0.0606253,0.0004374943],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997457,0.0006457463,0.0001366642,0.001041834,0.0002483362,0.0002228844,0.00001069176,0.000003165941,0.0002336586],"genre_scores_gemma":[0.9976582,0.0003401771,0.000746272,0.0007208376,0.0001351692,0.00001194241,0.00005930243,0.00001118873,0.0003169254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2277341,"threshold_uncertainty_score":0.2632967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07374213080268871,"score_gpt":0.3362450380260273,"score_spread":0.2625029072233386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}