{"id":"W2001505041","doi":"10.7785/tcrt.2012.500253","title":"Ultrasound-Activated Microbubble Cancer Therapy: Ceramide Production Leading to Enhanced Radiation Effect <i>in vitro</i>","year":2012,"lang":"en","type":"article","venue":"Technology in Cancer Research & Treatment","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Terry Fox Foundation","keywords":"Ceramide; Cancer research; Microbubbles; CD31; Apoptosis; Cancer cell; Endothelial stem cell; Cancer; Radiation therapy; Angiogenesis; Medicine; Pathology; Chemistry; In vitro; Ultrasound; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000185818,0.0004410942,0.0002841441,0.0001371473,0.00009540172,0.0001917047,0.0001560977,0.0002893672,0.001027716],"category_scores_gemma":[0.0001408243,0.0001226225,0.0002864663,0.000120048,0.0001641319,0.0001685878,0.0001124668,0.0003229774,0.0002940499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002371498,"about_ca_system_score_gemma":0.0001516547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007893945,"about_ca_topic_score_gemma":0.0007216845,"domain_scores_codex":[0.9998941,0.00002725426,0.00001020362,0.00001800557,0.00002836874,0.00002193319],"domain_scores_gemma":[0.9999464,0.00001442112,0.00001592897,0.000006609602,0.000008663734,0.000007970179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004483371,0.000007012817,0.00002579206,0.00002467071,0.000001874303,0.0000193879,0.00000682101,0.00003197826,0.999267,0.00002342466,0.00001399492,0.0005331776],"study_design_scores_gemma":[0.000002847578,0.00008945045,0.0001927211,0.000001082457,0.000003862809,0.00005414755,0.000001680836,0.0001381768,0.9992558,0.000004665276,0.0002547181,8.490136e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824529,0.003364026,0.01122041,0.0001361138,0.00004566198,0.00008873892,0.0002559309,0.0001741427,0.002262144],"genre_scores_gemma":[0.9848123,0.002054925,0.0100159,0.00008407885,0.00002050755,0.00008418565,0.0003702071,0.00003451481,0.002523427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027716,"threshold_uncertainty_score":0.003437996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03295966425835179,"score_gpt":0.3793136729305567,"score_spread":0.3463540086722049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}