{"id":"W2001505041","doi":"10.7785/tcrt.2012.500253","title":"Ultrasound-Activated Microbubble Cancer Therapy: Ceramide Production Leading to Enhanced Radiation Effect <i>in vitro</i>","year":2012,"lang":"en","type":"article","venue":"Technology in Cancer Research & Treatment","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Terry Fox Foundation","keywords":"Ceramide; Cancer research; Microbubbles; CD31; Apoptosis; Cancer cell; Endothelial stem cell; Cancer; Radiation therapy; Angiogenesis; Medicine; Pathology; Chemistry; In vitro; Ultrasound; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006769899,0.0002119613,0.0002753157,0.0005411484,0.0001119249,0.00001878927,0.0001834336,0.0002528271,0.00002213264],"category_scores_gemma":[0.0001574039,0.0001841438,0.00004693145,0.0009418984,0.00009869429,0.0000176916,0.00005387087,0.0002565103,0.00001420581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007710238,"about_ca_system_score_gemma":0.0001514446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001886698,"about_ca_topic_score_gemma":0.0004192746,"domain_scores_codex":[0.9980683,0.0002003831,0.0002138314,0.0005147944,0.0001777321,0.0008249924],"domain_scores_gemma":[0.9993664,0.0000455306,0.00005100275,0.0003754991,0.00007534468,0.00008624629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006422659,0.0001979751,0.01967935,0.00001056362,0.00005916225,0.000001370186,0.0003185351,0.0004095051,0.9124988,0.000008785961,0.0001801593,0.06599355],"study_design_scores_gemma":[0.001280381,0.000342153,0.00219466,0.00004234108,0.000007412433,0.000003781517,0.0000941519,0.000001825297,0.9877868,0.00003252062,0.008047237,0.0001667155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829421,0.01430992,0.00002528914,0.001156292,0.0003318543,0.001114104,0.00001280922,0.00004290136,0.00006475195],"genre_scores_gemma":[0.9863497,0.009977674,0.0001492928,0.00007349333,0.0004001666,0.002673399,0.00003901295,0.00003534557,0.0003019161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07528805,"threshold_uncertainty_score":0.7509167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03295966425835179,"score_gpt":0.3793136729305567,"score_spread":0.3463540086722049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}