{"id":"W2001512729","doi":"10.3389/fcell.2014.00069","title":"The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis","year":2014,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Lam Research; U.S. Department of Defense","keywords":"Tuberous sclerosis; TSC1; TSC2; Lymphangioleiomyomatosis; Neural crest; Biology; Pathology; Microphthalmia-associated transcription factor; Mutation; Cancer research; Gene; Genetics; Medicine; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017846,0.0001117509,0.000179553,0.0004527819,0.0002229501,0.0004270336,0.000215808,0.0002916755,0.0004749138],"category_scores_gemma":[0.0005343978,0.0001163823,0.0001190235,0.0002467849,0.0002484036,0.0001519613,0.0003550128,0.0002557947,0.00007714758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000186496,"about_ca_system_score_gemma":0.0001533874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001987136,"about_ca_topic_score_gemma":0.003294141,"domain_scores_codex":[0.9997764,0.00004249677,0.00002148691,0.00005627067,0.00006647977,0.00003687833],"domain_scores_gemma":[0.999755,0.00007436507,0.00008769637,0.00001819298,0.00003013528,0.00003462297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003806715,0.00003045652,0.2577034,0.0001027468,0.00007406417,0.005247361,0.0006710913,0.0003448723,0.7127453,0.001619246,0.0001761348,0.02090466],"study_design_scores_gemma":[0.00002476266,0.0002194098,0.912185,0.00005347719,0.0001834993,0.02621819,0.000818341,0.003119196,0.05171675,0.0009456927,0.004478963,0.00003678214],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9974559,0.0009789518,0.0004976034,0.00005181369,0.000003881826,0.000009883252,0.00006399681,0.00001127669,0.0009266474],"genre_scores_gemma":[0.9990419,0.0002771357,0.0004461991,0.00002431722,0.000003958502,0.000006019834,0.00005044087,0.000002964173,0.0001471346],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001987136,"threshold_uncertainty_score":0.003951192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06160165012218184,"score_gpt":0.3189848025627576,"score_spread":0.2573831524405758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}