{"id":"W2001528153","doi":"10.1126/science.1217277","title":"Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":350,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"U.S. National Library of Medicine; National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; Howard Hughes Medical Institute","keywords":"Epigenomics; Epigenetics; Enhancer; Colorectal cancer; Biology; Chromatin; Gene; Gene expression; Genetics; Gene signature; Cancer; Cancer research; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008638449,0.00007692176,0.000140783,0.0003296545,0.00007901995,0.0001866992,0.00007809808,0.0001159406,0.0007323376],"category_scores_gemma":[0.0002492594,0.0001049285,0.0000812718,0.0002610337,0.0001408192,0.0001131998,0.0001451792,0.0002190369,0.0001546418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009818944,"about_ca_system_score_gemma":0.00006685504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002752261,"about_ca_topic_score_gemma":0.000628574,"domain_scores_codex":[0.9999281,0.00001043467,0.000003072001,0.00002537228,0.00001619094,0.0000167164],"domain_scores_gemma":[0.9998388,0.00004185098,0.00004762356,0.00002198148,0.00002006872,0.00002963703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008343953,0.000004943258,0.008834556,0.00001332979,0.000007187358,0.00003822199,0.000018322,0.00007352384,0.9886689,0.00009340872,0.00002056737,0.002143675],"study_design_scores_gemma":[0.000007579502,0.0002051475,0.5418618,0.00000698451,0.00005115592,0.001471489,0.00007434451,0.002474902,0.4501062,0.0005619854,0.00316955,0.000008909093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931762,0.0004951414,0.004673134,0.000037687,0.000002811229,0.000007747823,0.0006071297,0.00007001921,0.0009302913],"genre_scores_gemma":[0.9965155,0.0002107361,0.002060122,0.00002867698,0.000004026618,0.000006752326,0.0006171437,0.00001511649,0.0005419166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007323376,"threshold_uncertainty_score":0.00244987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007427047514257928,"score_gpt":0.2650991367241232,"score_spread":0.2576720892098652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}