{"id":"W2001528153","doi":"10.1126/science.1217277","title":"Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":350,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"U.S. National Library of Medicine; National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; Howard Hughes Medical Institute","keywords":"Epigenomics; Epigenetics; Enhancer; Colorectal cancer; Biology; Chromatin; Gene; Gene expression; Genetics; Gene signature; Cancer; Cancer research; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330835,0.00006545887,0.00006837424,0.00002670299,0.00006978958,0.000008825581,0.0002225453,0.00005220067,0.00001260262],"category_scores_gemma":[0.00002951941,0.00005750633,0.00002828533,0.0001328635,0.0001906475,0.000005194961,0.00009912006,0.0000387143,0.000003189258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002046567,"about_ca_system_score_gemma":0.0001747342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001196333,"about_ca_topic_score_gemma":0.00001341784,"domain_scores_codex":[0.9993939,0.000007455579,0.00009994481,0.0001594972,0.00009826935,0.0002408685],"domain_scores_gemma":[0.9996188,0.000003292188,0.00007060471,0.0001731612,0.00007640897,0.00005770902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005805826,0.00001724238,0.008300583,0.00001149723,0.00000361141,4.609789e-8,0.00006891342,0.0001448045,0.9904087,0.0001803709,0.00002445075,0.0008339965],"study_design_scores_gemma":[0.00007508219,0.00003758217,0.00701559,0.000007381473,0.000004997175,0.000001799727,0.00004870498,0.0002699578,0.9913191,0.00005108169,0.001083789,0.00008492517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955181,0.00317793,0.0003441961,0.0000233204,0.0002767661,0.0000850512,0.00001453473,0.000003086407,0.0005569884],"genre_scores_gemma":[0.99662,0.0001722026,0.002845888,0.00005428992,0.0001143583,0.00001194237,0.00000577058,0.000006324429,0.0001692313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003005728,"threshold_uncertainty_score":0.234504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007427047514257928,"score_gpt":0.2650991367241232,"score_spread":0.2576720892098652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}