{"id":"W2001535876","doi":"10.1038/488165a","title":"Dynamic binding","year":2012,"lang":"en","type":"letter","venue":"Nature","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Biophysics; Protein dynamics; Nuclear magnetic resonance spectroscopy; Microsecond; DNA; Protein structure; Chemistry; DNA-binding protein; Crystallography; Nuclear magnetic resonance; Gene; Physics; Biology; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006051805,0.0006619876,0.0006872877,0.0004622805,0.002857359,0.002952906,0.001420874,0.004179746,0.06277689],"category_scores_gemma":[0.002209525,0.0005411737,0.0004659707,0.00040658,0.001775279,0.002950437,0.00239533,0.006467205,0.02186284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001698688,"about_ca_system_score_gemma":0.0007069703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007162727,"about_ca_topic_score_gemma":0.001103598,"domain_scores_codex":[0.9992051,0.00008409784,0.00002250932,0.0001823135,0.0003486128,0.0001574289],"domain_scores_gemma":[0.9994222,0.0001370503,0.00002939228,0.0001643366,0.0000846265,0.0001624512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001860081,0.00008007675,0.000198171,0.0001616645,0.00003814476,0.0009130208,0.0001152745,0.0004788597,0.02036512,0.4019369,0.5256844,0.0498424],"study_design_scores_gemma":[0.00003614812,0.00003977548,0.0001781118,0.00003090653,0.00001155109,0.001079098,0.0000790031,0.001558984,0.01024409,0.09282884,0.8938875,0.00002614672],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.01167372,0.01435107,0.03743147,0.1702474,0.06069083,0.0001256575,0.0006371167,0.001663321,0.7031794],"genre_scores_gemma":[0.245486,0.007391532,0.00848199,0.09997706,0.01190765,0.000374448,0.001077835,0.0005867141,0.6247167],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.06277689,"threshold_uncertainty_score":0.2100096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004112524813624568,"score_gpt":0.2291423562383467,"score_spread":0.2250298314247221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}