{"id":"W2001543190","doi":"10.1007/s00213-013-3391-3","title":"Evaluation of safety and tolerability, pharmacokinetics, and pharmacodynamics of BMS-820836 in healthy subjects: a placebo-controlled, ascending single-dose study","year":2013,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Centre for Addiction and Mental Health; Bristol-Myers Squibb","keywords":"Tolerability; Pharmacokinetics; Medicine; Pharmacodynamics; Placebo; Pharmacology; Serotonin transporter; Reuptake inhibitor; Antidepressant; Internal medicine; Anesthesia; Serotonin; Adverse effect; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001863824,0.002032738,0.00399087,0.0007299554,0.0007006473,0.0007460393,0.001149327,0.001947869,0.003332061],"category_scores_gemma":[0.001742187,0.001030636,0.001518259,0.0006671307,0.001614911,0.001322544,0.0004381036,0.002852079,0.0009341411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005939,"about_ca_system_score_gemma":0.001125288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117617,"about_ca_topic_score_gemma":0.001869434,"domain_scores_codex":[0.9989958,0.000467251,0.00008790281,0.0001933334,0.0001289032,0.0001268636],"domain_scores_gemma":[0.9989591,0.0002038068,0.000223357,0.0001544323,0.0001102659,0.0003490618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9188346,0.02509538,0.002241384,0.0003538409,0.0006812649,0.00009286242,0.0001254076,0.0003906808,0.03139564,0.00005772088,0.0003378555,0.02039339],"study_design_scores_gemma":[0.4607267,0.507356,0.02275272,0.00002156174,0.00106801,0.0001337105,0.00007023266,0.0009309562,0.006002963,0.0001203107,0.0007548556,0.00006188147],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996222,0.001155136,0.000476543,0.0001017749,0.00006572879,0.0009531419,0.0004746793,0.00008169299,0.0004693699],"genre_scores_gemma":[0.9938986,0.001066201,0.001386812,0.000370464,0.0002010106,0.0009727441,0.0006458253,0.00002999558,0.001428232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00399087,"threshold_uncertainty_score":0.01114678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03728414974871906,"score_gpt":0.3813764132755846,"score_spread":0.3440922635268656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}