{"id":"W2001544451","doi":"10.1016/j.cellsig.2006.05.020","title":"The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signalling","year":2006,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Heterotrimeric G protein; G protein-coupled receptor; MAPK/ERK pathway; Cell biology; G protein; HEK 293 cells; Scaffold protein; Signal transduction; Arrestin; Chemistry; Phosphorylation; Gq alpha subunit; Protein kinase A; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007262721,0.0003311965,0.0003157138,0.00006244238,0.0003800829,0.000112833,0.0004596149,0.0002675252,0.0001095998],"category_scores_gemma":[0.00005501835,0.0002605247,0.0002752979,0.0001752246,0.000117338,0.00001447822,0.0001369445,0.0002628181,0.00001391527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002586034,"about_ca_system_score_gemma":0.0000924633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001150302,"about_ca_topic_score_gemma":0.000009928362,"domain_scores_codex":[0.9978408,0.0002033625,0.0005053757,0.0005406038,0.0004099997,0.0004998542],"domain_scores_gemma":[0.9988834,0.00007125741,0.0003862394,0.0003932722,0.0001768128,0.00008899419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001349034,0.00008688363,0.0001181031,0.00003724601,0.00008002442,0.000003400802,0.00002082625,0.00935006,0.9877151,0.0001574014,0.00006113486,0.002234902],"study_design_scores_gemma":[0.0004340266,0.0002167325,0.00001842916,0.00008285265,0.00003155602,0.000001856669,0.0000367371,0.003382951,0.9922736,0.0005452302,0.002662888,0.0003131251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8800659,0.00385884,0.1151109,0.000027847,0.000188632,0.0004713515,0.000008850294,0.00002843725,0.0002392584],"genre_scores_gemma":[0.9959094,0.00007419945,0.002404215,0.00001407128,0.0004816804,0.00004720276,0.0000654085,0.00006521621,0.0009385894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1158435,"threshold_uncertainty_score":0.9999847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008399316026013966,"score_gpt":0.212273918825616,"score_spread":0.2038746027996021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}