{"id":"W2001558957","doi":"10.1055/s-2008-1078874","title":"CpG Motive in Plasmid DNA führen zur Verschlechterung der Lungenmechanik in Mäusen nach Aerosol Applikation eines nicht-viralen Genvektors","year":2008,"lang":"de","type":"article","venue":"Zeitschrift für Geburtshilfe und Neonatologie","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Plasmid; Molecular biology; Chemistry; CpG site; DNA; Biology; Gene; DNA methylation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0008757094,0.001211469,0.001601271,0.001542898,0.0008037587,0.00008353074,0.001231007,0.00227654,0.0009551955],"category_scores_gemma":[0.000797414,0.001253059,0.0004577067,0.001579521,0.0005424979,0.0007219574,0.0007001892,0.002104624,0.002327284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002542327,"about_ca_system_score_gemma":0.000858617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001174399,"about_ca_topic_score_gemma":0.0009177308,"domain_scores_codex":[0.9925758,0.001438039,0.001833357,0.001707294,0.000295724,0.00214983],"domain_scores_gemma":[0.9965118,0.00129491,0.0006459591,0.001126419,0.0002708138,0.0001501342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02060756,0.009907072,0.396549,0.001363202,0.01247969,0.006727569,0.02759737,0.002218351,0.3375233,0.09152974,0.06020455,0.03329256],"study_design_scores_gemma":[0.03295774,0.003126788,0.2113225,0.0009703724,0.002046712,0.0009521709,0.005222046,0.001660989,0.2580872,0.00104009,0.4761498,0.006463542],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8875642,0.1029148,0.0004602292,0.001606172,0.003194265,0.002106865,0.0002514823,0.000286396,0.001615621],"genre_scores_gemma":[0.9813253,0.01367429,0.0002958819,0.0004245676,0.0002087592,0.0003909095,0.00081945,0.0001478478,0.002712997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4159452,"threshold_uncertainty_score":0.999958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02318993638869101,"score_gpt":0.2832072494777795,"score_spread":0.2600173130890885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}