{"id":"W2001566658","doi":"10.1038/cdd.2010.142","title":"Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress","year":2010,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":343,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft; Hans und Ilse Breuer-Stiftung; National Institute of Diabetes and Digestive and Kidney Diseases; Heart and Stroke Foundation of Canada","keywords":"Parkin; Unfolded protein response; ATF4; Cell biology; Downregulation and upregulation; Endoplasmic reticulum; PINK1; Proteasome; Biology; Mitochondrion; Transcription factor; Programmed cell death; Autophagy; Mitophagy; Genetics; Apoptosis; Gene; Parkinson's disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335178,0.0002641625,0.0001737515,0.0002320253,0.0001594247,0.0002126818,0.0001248435,0.0001928664,0.0010406],"category_scores_gemma":[0.0001252222,0.00009056277,0.000142748,0.0001929838,0.0002797758,0.0001757761,0.0002147669,0.0002278548,0.0002615372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002426896,"about_ca_system_score_gemma":0.00009760328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002375936,"about_ca_topic_score_gemma":0.0002404181,"domain_scores_codex":[0.9999299,0.00001245874,0.000006011129,0.00001854488,0.00001861683,0.00001450837],"domain_scores_gemma":[0.999872,0.00001760659,0.00005313167,0.00001080867,0.00002000895,0.00002644968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002092151,0.00002387451,0.001237158,0.00006412982,0.000008386442,0.0002023069,0.00001962793,0.00004457774,0.9958537,0.000141306,0.00006572091,0.00213011],"study_design_scores_gemma":[0.00006388059,0.0004040296,0.08091872,0.00002510735,0.00006230519,0.00394626,0.0001108624,0.001492067,0.9029029,0.001220812,0.008840296,0.00001276613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874004,0.005994962,0.004280384,0.0004132403,0.00003730859,0.00001138542,0.0003322513,0.00009164571,0.001438525],"genre_scores_gemma":[0.9928218,0.00269618,0.002164753,0.0001073949,0.00003392345,0.00001574147,0.0006249581,0.00001714515,0.001518106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010406,"threshold_uncertainty_score":0.003481209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818391418644952,"score_gpt":0.2648173813545688,"score_spread":0.2466334671681193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}