{"id":"W2001566658","doi":"10.1038/cdd.2010.142","title":"Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress","year":2010,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":343,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft; Hans und Ilse Breuer-Stiftung; National Institute of Diabetes and Digestive and Kidney Diseases; Heart and Stroke Foundation of Canada","keywords":"Parkin; Unfolded protein response; ATF4; Cell biology; Downregulation and upregulation; Endoplasmic reticulum; PINK1; Proteasome; Biology; Mitochondrion; Transcription factor; Programmed cell death; Autophagy; Mitophagy; Genetics; Apoptosis; Gene; Parkinson's disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003799842,0.0001404338,0.0001104768,0.00002784407,0.0001072833,0.00008203328,0.00006469066,0.0001650772,0.00002142909],"category_scores_gemma":[0.00003491072,0.0001294523,0.00004938226,0.00001957095,0.00004037887,0.0000291325,0.00002036738,0.00006811802,3.661577e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003788326,"about_ca_system_score_gemma":0.00001699843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004348037,"about_ca_topic_score_gemma":0.00008766349,"domain_scores_codex":[0.9992045,0.00003198995,0.0001604848,0.0003695877,0.00008605168,0.0001473971],"domain_scores_gemma":[0.9995265,0.00002718482,0.00006903091,0.0001548835,0.00006941002,0.0001529641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002636336,0.00008143618,0.07714823,0.0001005059,0.00002760498,1.662817e-7,0.00006694025,0.000001843025,0.919885,0.00005996237,0.0005495314,0.001815092],"study_design_scores_gemma":[0.002099307,0.0005318546,0.176841,0.00006423152,0.00020016,0.000001881879,0.00006035316,0.001147696,0.817137,0.0004076969,0.001188997,0.000319843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992246,0.0005565379,0.006180085,0.00006605699,0.0002266833,0.0002697814,0.0004092677,0.00001132554,0.00003422001],"genre_scores_gemma":[0.997206,0.0002164585,0.0002348854,0.00005596413,0.000294838,0.00004007007,0.001740054,0.00001368588,0.0001980242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1027481,"threshold_uncertainty_score":0.5278912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818391418644952,"score_gpt":0.2648173813545688,"score_spread":0.2466334671681193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}