{"id":"W2001569469","doi":"10.1139/o09-168","title":"Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assemblyThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.","year":2010,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Hospital for Sick Children","funders":"","keywords":"Lipid-anchored protein; Apolipoprotein B; Biogenesis; Microsomal triglyceride transfer protein; Protein folding; Very low-density lipoprotein; Chemistry; Cell biology; Biochemistry; Vitellogenin; Chaperone (clinical); Ubiquitin; Intracellular; Lipoprotein; Autophagy; Biology; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002099573,0.0006139613,0.001627755,0.0001228803,0.00017779,0.00003647323,0.0003941066,0.001284583,0.0007799239],"category_scores_gemma":[0.0006697972,0.0005099075,0.0003104333,0.0003212851,0.00106157,0.00001761143,0.0003007643,0.0005482268,1.502613e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004273619,"about_ca_system_score_gemma":0.0007649634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001071269,"about_ca_topic_score_gemma":0.0002509333,"domain_scores_codex":[0.9964644,0.0004577623,0.001413036,0.0008881931,0.0002809324,0.0004956764],"domain_scores_gemma":[0.9969327,0.00007937073,0.001692098,0.0005187927,0.0005161506,0.0002608332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005780046,0.0001137031,0.0001011065,0.02729652,0.0002360347,6.408872e-7,0.0001653471,1.124328e-7,0.95454,0.0000315101,0.00007865918,0.01737862],"study_design_scores_gemma":[0.0004982009,0.000310018,0.000004073294,0.00367676,0.0004509891,0.00004048276,0.0001943108,0.00000480251,0.9083813,0.0002086511,0.08580365,0.0004267486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2179063,0.7790247,0.00007741867,0.0003132887,0.00004390316,0.001565436,0.000698052,0.000006864582,0.0003639842],"genre_scores_gemma":[0.2713288,0.7236453,0.003149836,0.00007169151,0.0004874617,0.0001648034,0.0008485492,0.00008391398,0.0002196777],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.08572499,"threshold_uncertainty_score":0.9997352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02977936282593255,"score_gpt":0.2684047972718276,"score_spread":0.2386254344458951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}