{"id":"W2001569469","doi":"10.1139/o09-168","title":"Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assemblyThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.","year":2010,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Hospital for Sick Children","funders":"","keywords":"Lipid-anchored protein; Apolipoprotein B; Biogenesis; Microsomal triglyceride transfer protein; Protein folding; Very low-density lipoprotein; Chemistry; Cell biology; Biochemistry; Vitellogenin; Chaperone (clinical); Ubiquitin; Intracellular; Lipoprotein; Autophagy; Biology; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000340634,0.0009047774,0.00118289,0.001832222,0.0002936014,0.000949725,0.000705382,0.0008942612,0.002374898],"category_scores_gemma":[0.0002819021,0.0002534191,0.0002386277,0.002471773,0.0003792544,0.001061039,0.0006262569,0.001100479,0.003556832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006933864,"about_ca_system_score_gemma":0.0009553309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008211292,"about_ca_topic_score_gemma":0.001458982,"domain_scores_codex":[0.9998792,0.00001231108,0.00001572593,0.00002185377,0.00005992575,0.00001084763],"domain_scores_gemma":[0.9998647,0.00003242063,0.00002089145,0.000005848954,0.0000523662,0.00002387253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003480234,0.00004411011,0.0001119804,0.005751051,0.00003520993,0.0001659458,0.00003713342,0.000234115,0.004596399,0.002423571,0.02142749,0.9651383],"study_design_scores_gemma":[0.000009792859,0.00004939998,0.0006548505,0.00103191,0.00003032519,0.001307461,0.00004647585,0.00007072819,0.001157888,0.001339889,0.994287,0.00001443624],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003109003,0.9954957,0.0005849161,0.0004090322,0.000298907,0.00001087324,0.00004037549,0.00002692,0.002822327],"genre_scores_gemma":[0.0007774434,0.9970223,0.0005352958,0.0001267405,0.0001090188,0.000008686347,0.00004973929,0.000002604689,0.001368189],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002374898,"threshold_uncertainty_score":0.007944763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02977936282593255,"score_gpt":0.2684047972718276,"score_spread":0.2386254344458951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}