{"id":"W2001570896","doi":"10.1182/blood-2014-10-606491","title":"Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Medical Research Council; Haematology Society of Australia and New Zealand; Wellcome Trust; March of Dimes Foundation; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Health and Medical Research Council; Bill and Melinda Gates Foundation","keywords":"Hepcidin; Thalassemia; Ineffective erythropoiesis; Erythropoiesis; Internal medicine; Medicine; Beta thalassemia; Anemia; Hemoglobinopathy; Immunology; Endocrinology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002942196,0.0001510416,0.0001832201,0.0003604114,0.0001528959,0.0002494441,0.00009689239,0.0001180157,0.0005601622],"category_scores_gemma":[0.001273493,0.0001048743,0.0001562819,0.0003274553,0.0003941313,0.00009597695,0.0001874411,0.0002532957,0.0000680654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001374609,"about_ca_system_score_gemma":0.0001486175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002872931,"about_ca_topic_score_gemma":0.001568883,"domain_scores_codex":[0.9997793,0.00007647915,0.00002152935,0.0000557063,0.00003651824,0.00003050829],"domain_scores_gemma":[0.9993269,0.0001507467,0.0002955646,0.00004800386,0.00007388664,0.0001049413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003094846,0.00001953514,0.9821227,0.000009346732,0.00004133216,0.0003920066,0.0001804261,0.00004890313,0.01286406,0.00007744919,0.00005673982,0.003878131],"study_design_scores_gemma":[0.000005251735,0.0001147801,0.9974017,0.000002755742,0.00002718892,0.001141632,0.00007784396,0.000132257,0.000922067,0.00003902165,0.0001332173,0.000002326823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995145,0.0001837363,0.00009825882,0.00001333788,0.000001389249,0.000001304633,0.00001909845,0.000002162965,0.0001661591],"genre_scores_gemma":[0.9998448,0.00003567535,0.00003030284,0.000009099838,0.000001632278,5.98612e-7,0.00002364459,8.367608e-7,0.00005326598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002872931,"threshold_uncertainty_score":0.00571245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005153191201622607,"score_gpt":0.2263172509107946,"score_spread":0.221164059709172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}