{"id":"W2001588476","doi":"10.1002/jat.1263","title":"Zinc toxicity alters mitochondrial metabolism and leads to decreased ATP production in hepatocytes","year":2007,"lang":"en","type":"article","venue":"Journal of Applied Toxicology","topic":"Trace Elements in Health","field":"Nursing","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"","keywords":"Aconitase; Isocitrate dehydrogenase; Mitochondrion; Biochemistry; Cytochrome c oxidase; NAD+ kinase; Oxidative phosphorylation; Metabolism; Biology; Toxicant; Glutamate dehydrogenase; Succinate dehydrogenase; Dehydrogenase; Chemistry; Toxicity; Cell biology; Enzyme; Glutamate receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000655816,0.0001980928,0.0002249811,0.0001988886,0.0001456265,0.0002054327,0.0001160183,0.0001792505,0.0006953308],"category_scores_gemma":[0.00009621015,0.0001102758,0.0001244197,0.0001498464,0.000163798,0.0001036346,0.0001365313,0.0001718314,0.0001737934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001927995,"about_ca_system_score_gemma":0.000119984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001632625,"about_ca_topic_score_gemma":0.001846761,"domain_scores_codex":[0.9999248,0.000018547,0.00000880268,0.00001295917,0.00001866818,0.00001619272],"domain_scores_gemma":[0.9999539,0.000008391909,0.00001192936,0.000007047819,0.000007687305,0.00001113019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007379112,0.00002644762,0.001724553,0.00003863938,0.000009603748,0.0002442331,0.00002371996,0.00006523098,0.995846,0.00003731332,0.00002784433,0.001218612],"study_design_scores_gemma":[0.00002458625,0.0006930009,0.01742998,0.000004819733,0.00002416649,0.0006567627,0.0001200199,0.0004862505,0.9795695,0.00008175668,0.0009050653,0.000004079597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975939,0.0009077531,0.0008217796,0.00003628255,0.00001213221,0.000005859204,0.0001070885,0.00002610415,0.0004889751],"genre_scores_gemma":[0.9982567,0.0004961531,0.0002380594,0.00001254713,0.000002893809,0.000005550386,0.0001068658,0.000004099641,0.0008771631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001632625,"threshold_uncertainty_score":0.003246248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01832860966945214,"score_gpt":0.3076931401946072,"score_spread":0.289364530525155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}