{"id":"W2001613191","doi":"10.1097/01.ede.0000173042.07579.17","title":"Evaluation of Nucleic Acid Amplification Tests in the Absence of a Perfect Gold-Standard Test","year":2005,"lang":"en","type":"article","venue":"Epidemiology","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Nucleic Acid Amplification Tests; Gold standard (test); Ligase chain reaction; Latent class model; Sensitivity (control systems); Computational biology; Applications of PCR; Conditional independence; Polymerase chain reaction; Statistics; Computer science; Medicine; Biology; Chlamydia trachomatis; Mathematics; Genetics; Gynecology; Engineering; Multiplex polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1259021,0.001342282,0.002409023,0.003646382,0.0006008819,0.00355819,0.002080899,0.002584165,0.0007186394],"category_scores_gemma":[0.2591444,0.0005879903,0.001281871,0.001592645,0.003679598,0.00262962,0.001643554,0.001446947,0.0004865728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001617378,"about_ca_system_score_gemma":0.001548021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001031194,"about_ca_topic_score_gemma":0.001128269,"domain_scores_codex":[0.8660673,0.08964131,0.008802813,0.00603333,0.02849266,0.0009626383],"domain_scores_gemma":[0.7543783,0.2074899,0.01403309,0.007140177,0.01585773,0.001100862],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002746257,0.0002553971,0.464702,0.003525861,0.001884143,0.001465331,0.001622183,0.01606971,0.009006496,0.0249432,0.005788648,0.4679907],"study_design_scores_gemma":[0.0003798517,0.009829049,0.3947813,0.004720683,0.004064856,0.01694837,0.003256941,0.2788547,0.1123134,0.1035828,0.07065795,0.0006100661],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3520665,0.09406508,0.5113907,0.01163059,0.001674506,0.0006525284,0.0009283099,0.0006652233,0.02692651],"genre_scores_gemma":[0.866774,0.007608132,0.121444,0.00170862,0.0005859717,0.0002107138,0.0003692401,0.0000799007,0.001219343],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8740979,"threshold_uncertainty_score":0.6658419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1086238937647002,"score_gpt":0.406121320869563,"score_spread":0.2974974271048627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}