{"id":"W2001701683","doi":"10.1038/nmeth.1941","title":"Phosphorylation sites of higher stoichiometry are more conserved","year":2012,"lang":"en","type":"letter","venue":"Nature Methods","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Stoichiometry; Computational biology; Chemistry; Biology; Evolutionary biology; Cell biology; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0009063152,0.000378131,0.0005206409,0.0001505859,0.00005258904,0.00001688917,0.0003896288,0.004925053,0.0002854919],"category_scores_gemma":[0.0003974437,0.0003297702,0.000299113,0.000202755,0.00008809914,0.000003709981,0.000123173,0.001519315,0.00000733929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001743255,"about_ca_system_score_gemma":0.00005383107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000615213,"about_ca_topic_score_gemma":8.969163e-7,"domain_scores_codex":[0.9977826,0.0007352641,0.0003285023,0.0004845758,0.0003302343,0.0003388072],"domain_scores_gemma":[0.9982591,0.0001621171,0.0005225574,0.0007784893,0.000220768,0.00005691793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004035214,0.00001861621,0.0003846348,0.0001812455,0.0001638067,0.000006061177,0.00001090616,4.000894e-7,0.6407485,0.00002381697,0.3537068,0.004714852],"study_design_scores_gemma":[0.00009836449,0.00003505667,0.0006737126,0.00003256445,0.00007216883,0.000004189729,0.000004256623,6.103071e-7,0.4852014,0.0001466039,0.5135231,0.0002079648],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.0465709,0.496189,0.06834016,0.352606,0.01687908,0.003710036,0.001467446,0.0002597759,0.01397762],"genre_scores_gemma":[0.03523785,0.0004589742,0.5216464,0.4001271,0.01271247,0.0001362679,0.003034053,0.0002821791,0.02636469],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.49573,"threshold_uncertainty_score":0.9999154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248729926154066,"score_gpt":0.346663863524405,"score_spread":0.3217908709089984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}