{"id":"W2001712666","doi":"10.1016/j.nbd.2014.10.012","title":"Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models","year":2014,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"UCLH Biomedical Research Centre; Medical Research Council; Rosetrees Trust; CHDI Foundation; University College London; National Institute for Health and Care Research; Cure Huntington's Disease Initiative","keywords":"Immune system; Huntington's disease; Huntingtin; Myeloid; Innate immune system; Inflammation; Neurodegeneration; Biology; Immunology; Huntingtin Protein; Cytokine; Bone marrow; Spleen; Phenotype; Disease; Cell biology; Medicine; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001234147,0.0002060853,0.000280516,0.0001787944,0.00005574493,0.00001035213,0.0001821097,0.0000445365,0.00002898578],"category_scores_gemma":[0.0003776209,0.0002043234,0.00009245413,0.0001414279,0.0002724546,0.0001484815,0.0001230175,0.0001059995,0.000005365031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009877687,"about_ca_system_score_gemma":0.00005777947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007329792,"about_ca_topic_score_gemma":0.000001687566,"domain_scores_codex":[0.9980398,0.0005218721,0.0004598757,0.0005782517,0.0001543544,0.0002457883],"domain_scores_gemma":[0.9988149,0.0001849529,0.0003068626,0.0004131347,0.00005383234,0.0002262653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008889618,0.0004906769,0.01313826,0.0001430512,0.000002199444,5.181147e-7,0.0000513581,0.002703398,0.9817269,0.0005160327,0.00001360006,0.0003249795],"study_design_scores_gemma":[0.0008796286,0.0003136356,0.369877,0.00001849183,0.00004813421,7.688468e-8,0.00001037947,0.002527423,0.6254233,0.000726368,0.00002201915,0.000153548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987217,0.0000445866,0.0002350708,0.0002167579,0.0001732205,0.0003811167,0.000130435,0.00002993027,0.00006721656],"genre_scores_gemma":[0.9992795,0.0001054008,0.00002604315,0.0004165504,0.00002829736,0.00004150762,0.0000316442,0.00002367771,0.00004739905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3567387,"threshold_uncertainty_score":0.8332066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368554488283925,"score_gpt":0.2147114661004914,"score_spread":0.2010259212176522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}