{"id":"W2001821674","doi":"10.1074/jbc.m111.317719","title":"A High Affinity Interaction of Plasminogen with Fibrin Is Not Essential for Efficient Activation by Tissue-type Plasminogen Activator","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; AstraZeneca Canada; AstraZeneca","keywords":"Chemistry; Tissue plasminogen activator; Plasminogen activator; Surface plasmon resonance; Fibrin; Cofactor; Binding site; T-plasminogen activator; Activator (genetics); Stereochemistry; Biochemistry; Molecular biology; Enzyme; Receptor; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101771,0.0002175865,0.0002557118,0.00008530224,0.0001141649,0.0003165027,0.000243344,0.0002353397,0.0009672099],"category_scores_gemma":[0.0003368314,0.0001702733,0.0002123147,0.00008707532,0.0001726479,0.0001793728,0.0001904122,0.0003426885,0.0003844931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936994,"about_ca_system_score_gemma":0.0001361193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005370321,"about_ca_topic_score_gemma":0.0006605797,"domain_scores_codex":[0.9997628,0.00005185484,0.00002326188,0.00004439831,0.00006350061,0.0000541016],"domain_scores_gemma":[0.9996548,0.00007900999,0.0001153683,0.00004153999,0.00002938292,0.0000798639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005800948,0.000009266543,0.0003568178,0.00001830113,0.000004515799,0.0000709041,0.000006838953,0.0000353343,0.9987798,0.00005124017,0.00002396577,0.0005849588],"study_design_scores_gemma":[0.00001049456,0.0001338565,0.01241995,0.000005853304,0.00001160792,0.0009258725,0.0000240741,0.001074344,0.9832182,0.00005480261,0.00211319,0.000007782944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959701,0.0008563372,0.002360473,0.00004688772,0.00001309584,0.000008709023,0.00008015813,0.00003107974,0.0006332304],"genre_scores_gemma":[0.9978518,0.0001385565,0.00118166,0.00002392732,0.000004549218,0.000006970869,0.0001675351,0.000008947632,0.0006160903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009672099,"threshold_uncertainty_score":0.003235638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04591322921802835,"score_gpt":0.2676076562664397,"score_spread":0.2216944270484113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}