{"id":"W2001821674","doi":"10.1074/jbc.m111.317719","title":"A High Affinity Interaction of Plasminogen with Fibrin Is Not Essential for Efficient Activation by Tissue-type Plasminogen Activator","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; AstraZeneca Canada; AstraZeneca","keywords":"Chemistry; Tissue plasminogen activator; Plasminogen activator; Surface plasmon resonance; Fibrin; Cofactor; Binding site; T-plasminogen activator; Activator (genetics); Stereochemistry; Biochemistry; Molecular biology; Enzyme; Receptor; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154408,0.0001185026,0.0003037958,0.0000223619,0.00003427202,0.000006449356,0.00007635409,0.000171857,0.0004342559],"category_scores_gemma":[0.0001161078,0.00007193916,0.00008641547,0.0000761715,0.00005783502,0.00005692081,0.00002145131,0.0001739594,0.000001265276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004749641,"about_ca_system_score_gemma":0.000062697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001558683,"about_ca_topic_score_gemma":1.065439e-7,"domain_scores_codex":[0.9991841,0.00001497831,0.0003634859,0.0001361168,0.0001780652,0.0001232797],"domain_scores_gemma":[0.9989759,0.00006474522,0.0004933112,0.00009678412,0.0002841587,0.00008512167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009771902,0.000368551,0.001143948,0.00009488727,0.0001291028,0.00000285835,0.0001318866,0.00001281743,0.9858963,0.000002818339,0.0004936905,0.001951274],"study_design_scores_gemma":[0.001329769,0.001772167,0.003649323,0.0001221467,0.00009897858,0.00008527725,0.0001518337,0.0000832237,0.9919199,0.00001716734,0.0006837769,0.00008646657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988836,0.00003891376,0.0004519357,0.0002271717,0.00007059898,0.0001455777,0.00001606694,0.000008403134,0.0001577042],"genre_scores_gemma":[0.9981166,0.00001499806,0.00146128,0.00006690621,0.0001916034,0.000003717106,0.00002259386,0.000008626045,0.0001137375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008442134,"threshold_uncertainty_score":0.4754797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04591322921802835,"score_gpt":0.2676076562664397,"score_spread":0.2216944270484113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}