{"id":"W2001828594","doi":"10.1002/pro.349","title":"Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms","year":2010,"lang":"en","type":"article","venue":"Protein Science","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Novartis Foundation; Merck; GlaxoSmithKline","keywords":"PDZ domain; Binding site; Plasma protein binding; Crystallography; Chemistry; Binding selectivity; Binding domain; Biophysics; Protein structure; Stereochemistry; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063264,0.0004113312,0.0003841459,0.0002509689,0.0004994036,0.0006683261,0.0005331582,0.0006148146,0.0013728],"category_scores_gemma":[0.0004918231,0.0003685802,0.0002617837,0.0002950516,0.0003488659,0.0007744458,0.0003695366,0.0008803416,0.0003647543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006122465,"about_ca_system_score_gemma":0.0002545429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009454497,"about_ca_topic_score_gemma":0.001170018,"domain_scores_codex":[0.9998761,0.00001286886,0.00001060182,0.00003458947,0.00004312311,0.00002268234],"domain_scores_gemma":[0.9998703,0.00004289452,0.00002904636,0.00001758161,0.00002233811,0.00001784614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003874236,0.0002025405,0.02906625,0.0006421366,0.000122529,0.002315435,0.0004866523,0.02485808,0.8877147,0.02366212,0.002677626,0.02786446],"study_design_scores_gemma":[0.0002845495,0.0002167602,0.05207397,0.00007491343,0.000184959,0.005513729,0.0006573452,0.2708847,0.6100978,0.03097706,0.02892593,0.0001083788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535383,0.00214234,0.03831834,0.000395145,0.00003413851,0.00004297261,0.0004284888,0.0005793396,0.004521055],"genre_scores_gemma":[0.9861385,0.0007935649,0.01152636,0.00009500745,0.00001006574,0.00003010703,0.0005555115,0.00004306312,0.0008077058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0013728,"threshold_uncertainty_score":0.004592538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396471102447586,"score_gpt":0.280052525535712,"score_spread":0.2660878145112361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}