{"id":"W2001828594","doi":"10.1002/pro.349","title":"Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms","year":2010,"lang":"en","type":"article","venue":"Protein Science","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Novartis Foundation; Merck; GlaxoSmithKline","keywords":"PDZ domain; Binding site; Plasma protein binding; Crystallography; Chemistry; Binding selectivity; Binding domain; Biophysics; Protein structure; Stereochemistry; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009474697,0.0001519264,0.0001105202,0.000253526,0.0003443888,0.0001233271,0.0004613895,0.00008544221,0.00005140099],"category_scores_gemma":[0.0002975365,0.0001406172,0.0000479822,0.0004788092,0.0002689617,0.00002548598,0.000181218,0.0003041772,0.00001981259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002915027,"about_ca_system_score_gemma":0.0002034863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000451359,"about_ca_topic_score_gemma":0.0002574363,"domain_scores_codex":[0.9984969,0.00004868284,0.0002080616,0.0005197482,0.0002902227,0.0004363206],"domain_scores_gemma":[0.9994066,0.00001292056,0.00008590307,0.0003016699,0.00006109498,0.0001317564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001482103,0.00002149819,0.0002054852,0.00000539692,0.000002504243,0.000006086936,0.0001808347,0.00001684227,0.9956971,0.002753332,0.000003588181,0.001092471],"study_design_scores_gemma":[0.0002152066,0.00008407,0.0001339076,0.00002570025,0.000001572998,0.0000327222,0.0004496495,0.0001005016,0.9952193,0.002299043,0.001244149,0.000194168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926847,0.0000155784,0.005738823,0.00009029337,0.0004208152,0.0002716266,0.00001729465,0.00002270776,0.0007381315],"genre_scores_gemma":[0.9852703,0.000001233499,0.01418326,0.00003496996,0.0001323099,0.00005658082,0.00001451828,0.00001412984,0.0002927367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008444433,"threshold_uncertainty_score":0.5734201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396471102447586,"score_gpt":0.280052525535712,"score_spread":0.2660878145112361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}