{"id":"W2001842045","doi":"10.1038/nsb0402-239","title":"How calpain is activated by calcium","year":2002,"lang":"en","type":"article","venue":"Nature Structural Biology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Calpain; Calcium; Chemistry; Mechanism (biology); Biophysics; Cell biology; Plasma protein binding; Calcium-binding protein; Biochemistry; Biology; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004751458,0.0001789287,0.0001341957,0.0000388815,0.0001073631,0.00002496285,0.0001291286,0.0009154661,0.0003263452],"category_scores_gemma":[0.00009455821,0.0001346255,0.00009409591,0.0001087115,0.0001125098,0.000004728089,0.00004908737,0.0003191734,0.000009043124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001873312,"about_ca_system_score_gemma":0.000008407905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008175833,"about_ca_topic_score_gemma":0.000004040718,"domain_scores_codex":[0.9990855,0.00009039856,0.0001114388,0.0003886046,0.00007396113,0.0002500319],"domain_scores_gemma":[0.9995253,0.000009458427,0.0000707644,0.0002350699,0.00007643113,0.00008295575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003925584,0.000005519543,0.0005050839,0.000004127,0.00003615485,5.393764e-7,0.00001205979,5.571774e-7,0.9068455,0.0001634079,0.08402128,0.008366546],"study_design_scores_gemma":[0.0004032273,0.0001327545,0.0005593335,0.000001797024,0.000007230848,0.00002397003,0.00001476026,0.0001428776,0.5797313,0.0001878271,0.418615,0.0001798804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847953,0.004256458,0.0006711977,0.008002395,0.000994151,0.0002822711,0.0001587973,0.00005609138,0.0007833142],"genre_scores_gemma":[0.9892841,0.00004390963,0.0001495113,0.002229845,0.0004333672,0.000008760814,0.000636625,0.00001487789,0.007198977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3345937,"threshold_uncertainty_score":0.7060913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006821526531301203,"score_gpt":0.244879000843512,"score_spread":0.2380574743122108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}