{"id":"W2001852778","doi":"10.1021/np100494u","title":"Triterpenoidal Alkaloids from<i>Buxus natalensis</i>and Their Acetylcholinesterase Inhibitory Activity","year":2010,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Merck Canada","keywords":"Acetylcholinesterase; Natural product; Stereochemistry; Phytochemical; Aché; Chemistry; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422109,0.0002716347,0.0005185938,0.0001891109,0.00009021855,0.00006373623,0.0001215314,0.0001066067,0.00002069239],"category_scores_gemma":[0.0009218276,0.0001739879,0.0001716401,0.000202756,0.0001323165,0.0005949138,0.00006796585,0.001288357,0.000005487606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002376577,"about_ca_system_score_gemma":0.0002044664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009552137,"about_ca_topic_score_gemma":0.00001037615,"domain_scores_codex":[0.9986553,0.00008253121,0.0004041576,0.0003255574,0.000310518,0.000221889],"domain_scores_gemma":[0.9982673,0.0001526727,0.000316287,0.0003226658,0.0006832315,0.0002578624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001298975,0.0002958727,0.001896052,0.00005497982,0.00008320797,0.0002455247,0.0002604748,2.721139e-7,0.9820727,0.000002813834,0.002480574,0.01130855],"study_design_scores_gemma":[0.002970848,0.0002143599,0.05744757,0.0001177783,0.0001359945,0.001802465,0.00003869577,0.00002345891,0.930282,0.00003494889,0.006731433,0.0002004814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890965,0.003997162,0.000002822222,0.004504444,0.002096787,0.0002180703,0.00003995595,0.00002135353,0.00002289279],"genre_scores_gemma":[0.9929075,0.0001751042,0.0004385218,0.001273253,0.004901162,0.000001593481,0.00001696795,0.0000286965,0.0002571609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05555151,"threshold_uncertainty_score":0.7095022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067854357003339,"score_gpt":0.2549085407491891,"score_spread":0.2442299971791557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}