{"id":"W2001862755","doi":"10.1007/s00125-004-1349-z","title":"Insulin expressing cells from differentiated embryonic stem cells are not beta cells","year":2004,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Stem Cell Network","keywords":"Proinsulin; Biology; Insulin; Embryonic stem cell; Stem cell; Cellular differentiation; Cell culture; Transplantation; Transfection; P19 cell; Cell biology; Internal medicine; Immunocytochemistry; Endocrinology; Cell type; Reporter gene; Cell; Molecular biology; Adult stem cell; Gene expression; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001364789,0.0004122423,0.0009258355,0.0001657261,0.0001465698,0.00007999301,0.0002213055,0.0003609009,0.000582757],"category_scores_gemma":[0.00003669924,0.0003430531,0.0002260849,0.0002885713,0.0001507815,0.0001190789,0.0001068499,0.0004338923,0.001199283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001585758,"about_ca_system_score_gemma":0.0001205752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008117036,"about_ca_topic_score_gemma":0.000004539447,"domain_scores_codex":[0.9976983,0.0001107323,0.0004991834,0.0006554825,0.0003821065,0.0006542075],"domain_scores_gemma":[0.9982852,0.0002758382,0.0002898155,0.0006970275,0.0001131519,0.0003390139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001255607,0.0004660911,0.01222584,0.0001094109,0.000188286,0.00007780515,0.0002074347,0.0001289402,0.9826524,0.0000374114,0.002288223,0.00149266],"study_design_scores_gemma":[0.003917624,0.0001610727,0.04750698,0.0003661834,0.000277811,0.000001475161,0.0002711369,0.0002503456,0.9458598,0.00009176063,0.0009456421,0.0003500927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950053,0.0009862053,0.0003851776,0.0003658749,0.001329894,0.0004144046,0.0001547683,0.0003690981,0.0009892842],"genre_scores_gemma":[0.9959354,0.00009769948,0.0008935636,0.001479291,0.0002042101,0.000032301,0.0001105754,0.00005522427,0.001191685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03679247,"threshold_uncertainty_score":0.9999021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02459185208154206,"score_gpt":0.2338625957155247,"score_spread":0.2092707436339826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}