{"id":"W2001862755","doi":"10.1007/s00125-004-1349-z","title":"Insulin expressing cells from differentiated embryonic stem cells are not beta cells","year":2004,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Stem Cell Network","keywords":"Proinsulin; Biology; Insulin; Embryonic stem cell; Stem cell; Cellular differentiation; Cell culture; Transplantation; Transfection; P19 cell; Cell biology; Internal medicine; Immunocytochemistry; Endocrinology; Cell type; Reporter gene; Cell; Molecular biology; Adult stem cell; Gene expression; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003570494,0.0002984876,0.0004707299,0.0003987675,0.0001707563,0.00133341,0.0003853086,0.0003800463,0.003026666],"category_scores_gemma":[0.0004163301,0.0003221649,0.0002914809,0.0003186469,0.000276743,0.0005510471,0.0002988632,0.001605967,0.002242571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002079053,"about_ca_system_score_gemma":0.0001075323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001560563,"about_ca_topic_score_gemma":0.0001666299,"domain_scores_codex":[0.9997597,0.00002680331,0.00002996439,0.00005205653,0.00008592926,0.00004558379],"domain_scores_gemma":[0.9991376,0.000289828,0.0001182837,0.0001483495,0.000131958,0.0001739468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003487959,0.00003103057,0.001628703,0.00004734413,0.00001933837,0.0001486347,0.00006758,0.00003012241,0.992433,0.0008426408,0.0001847389,0.004218304],"study_design_scores_gemma":[0.0001086366,0.0003711362,0.02414722,0.00002878526,0.000071624,0.002071869,0.0001800529,0.0006807957,0.9568261,0.0008919713,0.01460365,0.00001825786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681916,0.002310583,0.009572686,0.0003162593,0.0003518437,0.00004955244,0.001418781,0.0002435321,0.01754519],"genre_scores_gemma":[0.9731958,0.001266804,0.004539442,0.000461065,0.00008593861,0.00005709871,0.004327957,0.0002115204,0.01585434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003026666,"threshold_uncertainty_score":0.01012522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02459185208154206,"score_gpt":0.2338625957155247,"score_spread":0.2092707436339826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}