{"id":"W2001883600","doi":"10.1038/nchembio.221","title":"Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting","year":2009,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Purdue University","keywords":"Escherichia coli; Small molecule; Chemical biology; Pseudomonas aeruginosa; Bacteria; Biology; Drug discovery; Function (biology); Genomics; Computational biology; Gene; Genome; Phenotypic screening; Chemistry; Genetics; Microbiology; Biochemistry; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002471358,0.0004749376,0.0003616089,0.0004140778,0.0002263554,0.0006693772,0.0005993698,0.0005630264,0.001355145],"category_scores_gemma":[0.0003081879,0.0003284377,0.0003334316,0.0002182493,0.0004076174,0.0001999923,0.0002571736,0.0009449657,0.0007291325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00101611,"about_ca_system_score_gemma":0.0004834641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001519585,"about_ca_topic_score_gemma":0.001645745,"domain_scores_codex":[0.9997347,0.00003263005,0.00001600959,0.00004376831,0.000109316,0.00006364586],"domain_scores_gemma":[0.9997745,0.00006299066,0.0000600589,0.00001644178,0.00003218335,0.00005381807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009490513,0.00004543404,0.0001354169,0.00002009351,0.00000757421,0.00005725207,0.000005857754,0.0003099519,0.9971532,0.0005714986,0.0000842157,0.001514587],"study_design_scores_gemma":[0.00001228919,0.00006386931,0.000264324,0.000002035626,0.000008956089,0.00009691634,0.000004661497,0.001512865,0.9966323,0.00005354863,0.001344776,0.000003596225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9390547,0.001614691,0.04743745,0.001149152,0.0001394265,0.0001714634,0.0006267302,0.0008188803,0.008987429],"genre_scores_gemma":[0.9853436,0.0006105765,0.00896943,0.0002934914,0.00001815651,0.000046722,0.0004038132,0.0001165276,0.004197652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001519585,"threshold_uncertainty_score":0.007372439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004303538393154085,"score_gpt":0.2331671622567626,"score_spread":0.2288636238636085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}