{"id":"W2001892571","doi":"10.1371/journal.pone.0101022","title":"Development to Term of Cloned Cattle Derived from Donor Cells Treated with Valproic Acid","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Guelph","funders":"Foreign Affairs and International Trade Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Somatic cell nuclear transfer; Reprogramming; Epigenetics; Histone deacetylase; Histone; Somatic cell; DNA methylation; Biology; Acetylation; Chromatin; Andrology; Valproic Acid; Molecular biology; Cell biology; Embryo; Cell; Genetics; Embryogenesis; Blastocyst; DNA; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004287543,0.0002920155,0.0004602201,0.0003575667,0.0002949712,0.0004856095,0.0004351836,0.0004656308,0.002566905],"category_scores_gemma":[0.0004282213,0.0002163889,0.0004280083,0.0002148509,0.000239093,0.000302483,0.0004345789,0.0008598669,0.0007773401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004397189,"about_ca_system_score_gemma":0.0003694565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001996001,"about_ca_topic_score_gemma":0.002259955,"domain_scores_codex":[0.9996085,0.00005370547,0.00004093423,0.00009492411,0.0001067463,0.00009520607],"domain_scores_gemma":[0.9996141,0.0001174886,0.00006428193,0.00004010969,0.00005203029,0.0001120972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002526133,0.00003598704,0.0009704667,0.00003787196,0.00001184593,0.0003203207,0.0001292431,0.00003207189,0.9956946,0.00007268203,0.00003197197,0.002410307],"study_design_scores_gemma":[0.00006153165,0.002268191,0.03521267,0.00006943292,0.0001204776,0.002658452,0.000530773,0.0007892096,0.948719,0.0001016229,0.009445637,0.00002304608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915305,0.002024922,0.003032561,0.00007561935,0.0000613942,0.00005821301,0.0006483286,0.00003218616,0.002536298],"genre_scores_gemma":[0.9761865,0.002214541,0.004377739,0.0001269731,0.00002668427,0.0001181922,0.002706575,0.00006633121,0.01417644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002566905,"threshold_uncertainty_score":0.008587122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03716575843732438,"score_gpt":0.2293628768968233,"score_spread":0.1921971184594989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}