{"id":"W2001892571","doi":"10.1371/journal.pone.0101022","title":"Development to Term of Cloned Cattle Derived from Donor Cells Treated with Valproic Acid","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Guelph","funders":"Foreign Affairs and International Trade Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Somatic cell nuclear transfer; Reprogramming; Epigenetics; Histone deacetylase; Histone; Somatic cell; DNA methylation; Biology; Acetylation; Chromatin; Andrology; Valproic Acid; Molecular biology; Cell biology; Embryo; Cell; Genetics; Embryogenesis; Blastocyst; DNA; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163767,0.0001103084,0.0003467738,0.00003883847,0.00003571815,0.000002164455,0.00006477471,0.00006700381,0.0001076071],"category_scores_gemma":[0.00008503688,0.00007735637,0.00002094615,0.00008388465,0.00007394459,0.00001931363,0.00002789442,0.00007782123,0.0001180696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000037627,"about_ca_system_score_gemma":0.00005576246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005214151,"about_ca_topic_score_gemma":0.0000205112,"domain_scores_codex":[0.9991742,0.00004249683,0.000184669,0.000324312,0.0001291737,0.0001451333],"domain_scores_gemma":[0.9992997,0.00002990021,0.00005851763,0.0003852508,0.0001259416,0.0001007028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002426358,0.0009475358,0.1515987,0.00004749358,0.0002935761,0.000001632227,0.0004709208,1.345606e-7,0.8433123,7.109169e-7,0.00001342332,0.0008872096],"study_design_scores_gemma":[0.0004856063,0.0002432366,0.4754214,0.00006394689,0.00008263763,4.285822e-7,0.00001162404,0.000001647497,0.5236038,0.000004434255,0.0000324737,0.00004878663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984646,0.0000480277,0.0001820105,0.000220741,0.00001619111,0.0004408396,0.000009468574,0.00003833563,0.0005798033],"genre_scores_gemma":[0.9812428,0.000003411131,0.01812279,0.0001218683,0.00006546656,0.00003986064,0.00004980235,0.000011289,0.0003427358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3238227,"threshold_uncertainty_score":0.3154501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03716575843732438,"score_gpt":0.2293628768968233,"score_spread":0.1921971184594989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}