{"id":"W2001907971","doi":"10.1038/nature01268","title":"Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand","year":2002,"lang":"en","type":"article","venue":"Nature","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":320,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Brookhaven National Laboratory; RIKEN; Canadian Institutes of Health Research","keywords":"Inositol; Cell biology; Endoplasmic reticulum; Biology; Binding site; Inositol trisphosphate receptor; Caenorhabditis elegans; Receptor; Biochemistry; Biophysics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001797638,0.0003304452,0.0004721107,0.0003448172,0.0007795636,0.0006580637,0.001082615,0.0005939844,0.002884826],"category_scores_gemma":[0.0003832364,0.0003081799,0.0002449941,0.0003452479,0.000395193,0.0004680406,0.0003948128,0.001318855,0.0005693253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00209772,"about_ca_system_score_gemma":0.0009370989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008264071,"about_ca_topic_score_gemma":0.007307639,"domain_scores_codex":[0.9998796,0.00001283978,0.000004229556,0.00002743081,0.00003053543,0.0000454477],"domain_scores_gemma":[0.9997537,0.00004272727,0.00004376088,0.00001599595,0.0000275863,0.0001163638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001848328,0.0003318891,0.0012384,0.0001775716,0.00005161894,0.001196367,0.0003123434,0.004912814,0.9678331,0.01077282,0.003387035,0.007937807],"study_design_scores_gemma":[0.0002608642,0.0008077155,0.04541598,0.00009625861,0.0001267272,0.00199535,0.0006784392,0.08622052,0.834727,0.004494592,0.02497408,0.0002023298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987491,0.001559088,0.003430273,0.0006396033,0.0001087204,0.00003696648,0.0003714556,0.0001958036,0.006166982],"genre_scores_gemma":[0.9925517,0.0004301799,0.001784121,0.0004022433,0.00002150416,0.00001569738,0.0009855155,0.00002659778,0.003782366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008264071,"threshold_uncertainty_score":0.01643193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354780923729159,"score_gpt":0.2407533464617251,"score_spread":0.2272055372244335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}