{"id":"W2001916053","doi":"10.1016/j.cub.2015.01.065","title":"Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense","year":2015,"lang":"en","type":"article","venue":"Current Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; University of New Brunswick","funders":"Natural Environment Research Council; Biotechnology and Biological Sciences Research Council; AXA Research Fund; European Commission; Sight Research UK; Leverhulme Trust","keywords":"CRISPR; Biology; Genome; Palindrome; Genetics; Defence mechanisms; Immune system; Computational biology; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866887,0.0002189098,0.000231508,0.0002658921,0.0001706771,0.0007518675,0.0003480835,0.0004061364,0.002358385],"category_scores_gemma":[0.0002889938,0.0002485031,0.0001903701,0.0001877808,0.0003640672,0.000264879,0.0006191611,0.001185201,0.0004926872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004517021,"about_ca_system_score_gemma":0.0002404035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264952,"about_ca_topic_score_gemma":0.0009885243,"domain_scores_codex":[0.9997265,0.00003830002,0.0000151799,0.00006522612,0.00007473578,0.00008007097],"domain_scores_gemma":[0.9996781,0.00008208287,0.00007696293,0.00005648229,0.00002531142,0.00008110359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004671642,0.00001898838,0.0005586704,0.000009907289,0.000003716282,0.00003197795,0.00001271697,0.00003827018,0.9978164,0.0002627773,0.00003383289,0.001165987],"study_design_scores_gemma":[0.00002448885,0.0002547466,0.03835202,0.000009601436,0.00003773924,0.0007518681,0.0001754441,0.003826526,0.952885,0.0004805154,0.003178462,0.00002360855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996002,0.0001633526,0.001641855,0.0001247358,0.00001773226,0.000006290562,0.00007323969,0.00008402972,0.001886755],"genre_scores_gemma":[0.9977111,0.00009055544,0.0005501237,0.00007737075,0.00000553231,0.000005452943,0.00009675485,0.00003727199,0.001425826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002358385,"threshold_uncertainty_score":0.007889569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0309519072515461,"score_gpt":0.366742456619212,"score_spread":0.3357905493676658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}