{"id":"W2001916053","doi":"10.1016/j.cub.2015.01.065","title":"Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense","year":2015,"lang":"en","type":"article","venue":"Current Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; University of New Brunswick","funders":"Natural Environment Research Council; Biotechnology and Biological Sciences Research Council; AXA Research Fund; European Commission; Sight Research UK; Leverhulme Trust","keywords":"CRISPR; Biology; Genome; Palindrome; Genetics; Defence mechanisms; Immune system; Computational biology; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002547,0.0001136471,0.0001370205,0.00005094838,0.00002334672,0.000002707566,0.00009398314,0.0001295073,0.000002893531],"category_scores_gemma":[0.0001710188,0.0001079057,0.00005262879,0.00009539872,0.0001597962,0.000002210655,0.00006389571,0.00008229683,0.000007592567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002863176,"about_ca_system_score_gemma":0.0001490976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000135971,"about_ca_topic_score_gemma":0.00002045118,"domain_scores_codex":[0.9993322,0.00005307783,0.000145934,0.0002448123,0.00004443981,0.0001795037],"domain_scores_gemma":[0.9995254,0.000015093,0.00005989429,0.0001761368,0.0001479147,0.00007555687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001009468,0.0002264117,0.1223029,0.00004468992,0.0002658691,0.000001563511,0.0006022133,0.001541765,0.8495947,0.008311543,0.003029416,0.01306939],"study_design_scores_gemma":[0.005684963,0.003565701,0.02103482,0.00004618125,0.0001122468,0.00002596476,0.0006830774,0.0001832738,0.8830374,0.001281726,0.08368466,0.0006600096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962047,0.01167831,0.02310228,0.00001192648,0.001322102,0.000139575,0.00003686536,0.00001399902,0.001647962],"genre_scores_gemma":[0.9992621,0.000144893,0.000287855,0.000003996835,0.0001682785,0.00001288066,0.00009661151,0.000006614295,0.00001677529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1012681,"threshold_uncertainty_score":0.4400267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0309519072515461,"score_gpt":0.366742456619212,"score_spread":0.3357905493676658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}