{"id":"W2001938126","doi":"10.1089/zeb.2011.0702","title":"Fasted Zebrafish Mimic Genetic and Physiological Responses in Mammals: A Model for Obesity and Diabetes?","year":2011,"lang":"en","type":"article","venue":"Zebrafish","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Zebrafish; Biology; Endocrinology; Internal medicine; AMPK; Glycogen; Glucokinase; Phosphoenolpyruvate carboxykinase; Sterol regulatory element-binding protein; Danio; Lipogenesis; Protein kinase A; Lipid metabolism; Insulin; Kinase; Biochemistry; Sterol; Enzyme; Gene; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002957346,0.0006266817,0.0005318097,0.0005144003,0.0005519126,0.0006431996,0.00062109,0.001019622,0.003308184],"category_scores_gemma":[0.0002244988,0.000319147,0.0004605572,0.0002617942,0.0008595065,0.0008270878,0.0005877634,0.001736944,0.0007859819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007651916,"about_ca_system_score_gemma":0.0005690725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002932048,"about_ca_topic_score_gemma":0.007368444,"domain_scores_codex":[0.9997862,0.00002682924,0.00001873347,0.00006527538,0.00005608013,0.0000468257],"domain_scores_gemma":[0.999878,0.00001132048,0.00003359407,0.00001835723,0.00002043936,0.00003831847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007153444,0.0001189061,0.001657485,0.000343979,0.00004390079,0.0005852379,0.0001679016,0.0002454966,0.9800532,0.004784303,0.00158291,0.009701212],"study_design_scores_gemma":[0.0007418763,0.00820552,0.05221522,0.000625979,0.0005919014,0.007181339,0.001664508,0.005215453,0.7651995,0.01054966,0.1474959,0.0003131339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9018098,0.0150608,0.04908152,0.008126818,0.001991602,0.0006833061,0.007665331,0.001384494,0.01419623],"genre_scores_gemma":[0.8791417,0.0129098,0.06039573,0.002576727,0.0001611994,0.00182937,0.00316522,0.0002758495,0.03954444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003308184,"threshold_uncertainty_score":0.01106697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06547888428150031,"score_gpt":0.263160490432892,"score_spread":0.1976816061513917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}