{"id":"W2001946080","doi":"10.1002/ijc.25870","title":"Cancer risks for monoallelic <i>MUTYH</i> mutation carriers with a family history of colorectal cancer","year":2010,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; Cancer Care Ontario; Mount Sinai Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Medicine; Cancer; Colorectal cancer; MUTYH; Endometrial cancer; Population; Family history; Internal medicine; Cancer registry; Lynch syndrome; Oncology; Gynecology; Mutation; Germline mutation; Genetics; Biology; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002031716,0.0001966151,0.0004171604,0.0002460512,0.00002320159,0.0000129378,0.0003024835,0.0001349864,0.0006201624],"category_scores_gemma":[0.000106023,0.0001562981,0.0002092732,0.0001020246,0.0002222108,0.0001414286,0.00002529517,0.0004333027,8.989978e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001578031,"about_ca_system_score_gemma":0.003469554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002115775,"about_ca_topic_score_gemma":0.003534027,"domain_scores_codex":[0.9980991,0.00002008458,0.000571268,0.0002088487,0.000887605,0.0002130501],"domain_scores_gemma":[0.9961822,0.0001110149,0.0008217389,0.0001153298,0.002598785,0.0001709026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01682357,0.00030174,0.1698762,0.0001894814,0.004200383,0.00008896321,0.003297781,0.01028022,0.6318579,0.0001581129,0.03104817,0.1318775],"study_design_scores_gemma":[0.02351076,0.003608181,0.3728467,0.001756232,0.002309304,0.0005739325,0.0006521982,0.003087583,0.2533497,0.0003761463,0.3369987,0.0009306169],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781891,0.01026224,0.0004459137,0.001380214,0.008463962,0.0003991052,0.0001842969,0.000012049,0.0006631376],"genre_scores_gemma":[0.9937031,0.001353594,0.002204899,0.0007782348,0.001169139,0.0002426258,0.000006808937,0.00004624153,0.0004953708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3785082,"threshold_uncertainty_score":0.6790344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02674987241430809,"score_gpt":0.3408707904724694,"score_spread":0.3141209180581613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}