{"id":"W2001946080","doi":"10.1002/ijc.25870","title":"Cancer risks for monoallelic <i>MUTYH</i> mutation carriers with a family history of colorectal cancer","year":2010,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; Cancer Care Ontario; Mount Sinai Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Medicine; Cancer; Colorectal cancer; MUTYH; Endometrial cancer; Population; Family history; Internal medicine; Cancer registry; Lynch syndrome; Oncology; Gynecology; Mutation; Germline mutation; Genetics; Biology; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003255342,0.0001386943,0.0001975804,0.0005208466,0.0002044157,0.0002104849,0.0001274489,0.0002402703,0.001222221],"category_scores_gemma":[0.00165166,0.00015753,0.0003109068,0.0003873972,0.0001533018,0.0001367032,0.0001677273,0.0002401711,0.0001150691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427116,"about_ca_system_score_gemma":0.0002083401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02098908,"about_ca_topic_score_gemma":0.0218851,"domain_scores_codex":[0.9998399,0.00004145606,0.0000119644,0.00005195338,0.00002134543,0.00003346834],"domain_scores_gemma":[0.9994317,0.0001312268,0.0002510085,0.00005129059,0.00004509673,0.00008954814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001371503,0.000007972468,0.9977851,0.000005261671,0.00004524368,0.0001606931,0.00002949942,0.00007279358,0.0002781252,0.00002102686,0.00008722926,0.001369936],"study_design_scores_gemma":[0.000006601994,0.00006965376,0.9985152,0.000003447116,0.00005928957,0.000734461,0.00003833213,0.0002534845,0.0001017392,0.00003308595,0.0001817326,0.000003018957],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991308,0.0002515074,0.00008276814,0.00002428601,0.000002273339,0.000002865516,0.000178607,0.000004662988,0.0003223382],"genre_scores_gemma":[0.9995505,0.00007958469,0.00007314882,0.0000105771,0.000003027554,0.000002259167,0.0001440628,9.287123e-7,0.0001359467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02098908,"threshold_uncertainty_score":0.04173386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02674987241430809,"score_gpt":0.3408707904724694,"score_spread":0.3141209180581613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}