{"id":"W2001946221","doi":"10.1016/j.mad.2011.11.008","title":"Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease","year":2011,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Oxidative stress; Internal medicine; Efflux; Cholesterol; Endocrinology; Inflammation; Medicine; Transporter; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000331448,0.0002897285,0.0004684765,0.000436899,0.0002446712,0.000497899,0.0001657785,0.0003605631,0.001082473],"category_scores_gemma":[0.0002964527,0.0001903948,0.0002040895,0.000267823,0.0002769038,0.0003448225,0.0001956699,0.0006131276,0.000239717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347273,"about_ca_system_score_gemma":0.000233271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008132077,"about_ca_topic_score_gemma":0.0007960382,"domain_scores_codex":[0.9998797,0.00003627366,0.00001856427,0.00001117819,0.00002530139,0.0000289499],"domain_scores_gemma":[0.9998391,0.00002115285,0.00006272963,0.00001503158,0.00002986256,0.0000320783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01117264,0.0005903781,0.02724189,0.0004547435,0.0002929835,0.002094936,0.0002483549,0.0002303532,0.8925954,0.00198362,0.0009143304,0.06218046],"study_design_scores_gemma":[0.00076177,0.003073044,0.6325812,0.0000737438,0.0008335479,0.01268549,0.0005518515,0.002862654,0.3298796,0.00478751,0.01184123,0.00006835495],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891131,0.00935735,0.0003011612,0.0003113601,0.00002151829,0.000004881951,0.00006645949,0.00002239333,0.0008018541],"genre_scores_gemma":[0.9949706,0.003344332,0.0002941813,0.00007903313,0.00003223168,0.00001023072,0.00008920227,0.000003602649,0.001176616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082473,"threshold_uncertainty_score":0.00362128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02324470028105873,"score_gpt":0.2169745751278183,"score_spread":0.1937298748467596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}