{"id":"W2001966498","doi":"10.1124/dmd.108.020388","title":"Aldo-Keto Reductase 1C2 Fails to Metabolize Doxorubicin and Daunorubicin in Vitro","year":2008,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Daunorubicin; Reductase; Anthracycline; Metabolite; Doxorubicin; Aldo-keto reductase; Biochemistry; In vitro; Chemistry; Recombinant DNA; Enzyme; In vivo; Pharmacology; Biology; Chemotherapy; Immunology; Cancer; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006428656,0.0006073861,0.0009350632,0.0005519718,0.0003314805,0.0006426836,0.0007286036,0.0005510214,0.002489985],"category_scores_gemma":[0.001182403,0.0004537948,0.000469903,0.0005623925,0.0003337748,0.0003529552,0.0003678717,0.0009743798,0.001757562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005503713,"about_ca_system_score_gemma":0.0004394664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005647982,"about_ca_topic_score_gemma":0.002323605,"domain_scores_codex":[0.9991112,0.0002097438,0.0001172986,0.0001678902,0.0002553691,0.0001384493],"domain_scores_gemma":[0.9992087,0.0003304984,0.00007055827,0.0001373998,0.0001154863,0.0001373736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008406717,0.0003017166,0.002075016,0.00008375555,0.0001040929,0.0007342963,0.00007560589,0.0003977306,0.991147,0.0003025502,0.0007820923,0.003155535],"study_design_scores_gemma":[0.00008142026,0.0008071265,0.008735479,0.000009662742,0.00006209772,0.003112679,0.0001108617,0.004021577,0.9749408,0.0001039483,0.007993368,0.00002087013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883085,0.003237667,0.003287114,0.0004329359,0.0002796557,0.000064198,0.001649501,0.0001517527,0.002588691],"genre_scores_gemma":[0.9821234,0.0008307741,0.001808576,0.0001213436,0.00006802242,0.00005842949,0.009249453,0.0001595664,0.005580475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005647982,"threshold_uncertainty_score":0.01123023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006057366164270048,"score_gpt":0.2253110588636314,"score_spread":0.2192536926993613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}