{"id":"W2001966776","doi":"10.1074/jbc.m114.583823","title":"Cdx1 and Cdx2 Function as Tumor Suppressors","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Colorectal cancer; CDX2; Mouse model of colorectal and intestinal cancer; Biology; Cancer research; Wnt signaling pathway; Carcinogenesis; Microsatellite instability; Adenomatous polyposis coli; Transcription factor; Cancer; Germline mutation; Allele; Mutation; Genetics; Homeobox; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289803,0.0004155372,0.0001341473,0.0002006153,0.0001689673,0.0003598757,0.00015534,0.0002658828,0.001109708],"category_scores_gemma":[0.00009142946,0.0001262157,0.0001039028,0.000103782,0.0002605543,0.0002089877,0.0003001493,0.0002497523,0.0002232462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002912645,"about_ca_system_score_gemma":0.0001468917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002660349,"about_ca_topic_score_gemma":0.0004110597,"domain_scores_codex":[0.9999062,0.00001532679,0.000005714539,0.00003305079,0.00002607058,0.00001366469],"domain_scores_gemma":[0.9999495,0.000004843227,0.00001637505,0.000004444055,0.000003286499,0.00002159735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002459511,0.00002003211,0.001519729,0.00007127207,0.000006848532,0.0001324606,0.00001700804,0.0001866458,0.9927655,0.00100378,0.0001004555,0.003930204],"study_design_scores_gemma":[0.00005941403,0.0002990072,0.02248005,0.00001313963,0.00002135133,0.001330229,0.00004865807,0.00162878,0.9532279,0.0005635595,0.0203183,0.000009519173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808882,0.0108862,0.004064398,0.0002578213,0.00006049234,0.000031981,0.0003738681,0.0001064728,0.0033307],"genre_scores_gemma":[0.9895145,0.00298754,0.002360888,0.00005438559,0.00001854601,0.00002493285,0.000316624,0.00001454817,0.004707943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001109708,"threshold_uncertainty_score":0.003712356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00948877601313434,"score_gpt":0.243366556045734,"score_spread":0.2338777800325997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}