{"id":"W2001966776","doi":"10.1074/jbc.m114.583823","title":"Cdx1 and Cdx2 Function as Tumor Suppressors","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Colorectal cancer; CDX2; Mouse model of colorectal and intestinal cancer; Biology; Cancer research; Wnt signaling pathway; Carcinogenesis; Microsatellite instability; Adenomatous polyposis coli; Transcription factor; Cancer; Germline mutation; Allele; Mutation; Genetics; Homeobox; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003731019,0.0001133166,0.0001945294,0.00001264863,0.0000528278,0.00001431358,0.0001091283,0.0002319172,0.00005519645],"category_scores_gemma":[0.0002993732,0.00007270095,0.00008842166,0.00003462621,0.00009948537,0.000003071218,0.00004860429,0.000182058,0.000006278834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008972714,"about_ca_system_score_gemma":0.00004078334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001693801,"about_ca_topic_score_gemma":1.218402e-7,"domain_scores_codex":[0.9992255,0.0000621076,0.0002917844,0.0001653053,0.00009445943,0.0001608273],"domain_scores_gemma":[0.9993642,0.00002649892,0.0002354516,0.0001057313,0.0001068044,0.000161312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002332838,0.00005177431,0.008272972,0.00004255271,0.00004558917,0.000008615137,0.000007247591,0.000007588145,0.9890866,0.00004681824,0.001093612,0.001103381],"study_design_scores_gemma":[0.001425097,0.002318888,0.02520525,0.00009914635,0.00004764343,0.001442161,0.0001639257,0.00001425706,0.8077526,0.0008607336,0.1603724,0.0002978577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914182,0.001094182,0.0002436474,0.0001647099,0.0001425529,0.00003651708,0.000002579955,0.000005183719,0.006892434],"genre_scores_gemma":[0.9983348,0.0002481273,0.00009619173,0.0002913253,0.0005572021,0.000001236191,0.00001027799,0.000006766693,0.0004541115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.181334,"threshold_uncertainty_score":0.2964659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00948877601313434,"score_gpt":0.243366556045734,"score_spread":0.2338777800325997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}