{"id":"W2001970783","doi":"10.1139/w99-142","title":"Oral immunization of mice with a glycoconjugate vaccine containing the O157 antigen of<i>Escherichia coli</i>O157:H7 admixed with cholera toxin fails to elicit protection against subsequent colonization by the pathogen","year":2000,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cholera toxin; Microbiology; Adjuvant; Immune system; Glycoconjugate; Biology; Antigen; Escherichia coli; Vibrio cholerae; Vaccination; Cholera vaccine; Immunization; Cholera; Colonization; Immunity; Immunology; Virology; Bacteria; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004806501,0.0008259983,0.0005987022,0.0005031675,0.0003080519,0.0004833499,0.0003659736,0.001052936,0.001613249],"category_scores_gemma":[0.0002226778,0.0003426803,0.0004046444,0.0001622923,0.0006204433,0.0005329491,0.0002030485,0.001728753,0.0006048221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004165773,"about_ca_system_score_gemma":0.00040733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001015207,"about_ca_topic_score_gemma":0.001365531,"domain_scores_codex":[0.9996313,0.0000400388,0.00002574736,0.0001076286,0.00006941128,0.0001259636],"domain_scores_gemma":[0.9996008,0.00005951092,0.0001090789,0.00005659168,0.00003889464,0.0001351633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001052318,0.000582086,0.0004072773,0.00006380091,0.00001685609,0.00005701596,0.00004589888,0.00007205313,0.9962451,0.0001841901,0.00009897759,0.001174358],"study_design_scores_gemma":[0.0003028041,0.01608543,0.007152121,0.00004535959,0.00008902897,0.0004908535,0.00009659756,0.0008947981,0.971393,0.0001973253,0.003235321,0.0000174059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947218,0.0006369255,0.001501793,0.0002652105,0.0001118157,0.00007449112,0.0003670478,0.0001473017,0.002173703],"genre_scores_gemma":[0.988576,0.0009921946,0.002281026,0.0004117073,0.00005251023,0.00009479075,0.001108196,0.00005726416,0.006426379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613249,"threshold_uncertainty_score":0.005396903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008394983464380048,"score_gpt":0.2171902158045142,"score_spread":0.2087952323401341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}