{"id":"W2001998267","doi":"10.1210/me.2003-0217","title":"An Activator Protein 1-Like Motif Mediates 17β-Estradiol Repression of Gonadotropin-Releasing Hormone Receptor Promoter via an Estrogen Receptor α-Dependent Mechanism in Ovarian and Breast Cancer Cells","year":2003,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"GNRHR; Biology; CREB-binding protein; Molecular biology; Psychological repression; Activator (genetics); Estrogen receptor; Estrogen-related receptor gamma; CREB; Hormone response element; Receptor; Cell biology; Transcription factor; Endocrinology; Gene expression; Nuclear receptor; Gonadotropin-releasing hormone; Gene; Biochemistry; Genetics; Hormone; Luteinizing hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001444504,0.0004130359,0.0004397094,0.0001574997,0.00008731298,0.00002511937,0.0002855535,0.0004876512,0.00004441218],"category_scores_gemma":[0.00003173289,0.0003906102,0.00009827285,0.0001487319,0.0001657306,0.00002887556,0.0001016762,0.0003851923,0.000005204397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005773093,"about_ca_system_score_gemma":0.0001449753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000282568,"about_ca_topic_score_gemma":0.000009598751,"domain_scores_codex":[0.9970223,0.0006765921,0.0004536363,0.0009429491,0.000214394,0.0006901312],"domain_scores_gemma":[0.9987364,0.0000101104,0.000230565,0.0006546383,0.00008980852,0.0002785118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003719364,0.0003682367,0.000563883,0.00003769016,0.0001314192,0.00008172725,0.00009109089,0.00006229925,0.9946615,0.0005093898,0.00001042113,0.003110453],"study_design_scores_gemma":[0.00166641,0.001108986,0.001180164,0.0000500455,0.00004271709,0.0003108909,0.00006106186,0.0001159482,0.9947195,0.0002012731,0.0001428822,0.0004000881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995198,0.002085224,0.001357895,0.0001082377,0.0002201178,0.0009100758,0.00005929774,0.00003076579,0.00003044379],"genre_scores_gemma":[0.9945649,0.0006082326,0.004283215,0.00006525044,0.0000752924,0.0001686234,0.0001157212,0.00008508594,0.00003368199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00292532,"threshold_uncertainty_score":0.9998546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004690607670135373,"score_gpt":0.2288237082808867,"score_spread":0.2241331006107513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}