{"id":"W2001998267","doi":"10.1210/me.2003-0217","title":"An Activator Protein 1-Like Motif Mediates 17β-Estradiol Repression of Gonadotropin-Releasing Hormone Receptor Promoter via an Estrogen Receptor α-Dependent Mechanism in Ovarian and Breast Cancer Cells","year":2003,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"GNRHR; Biology; CREB-binding protein; Molecular biology; Psychological repression; Activator (genetics); Estrogen receptor; Estrogen-related receptor gamma; CREB; Hormone response element; Receptor; Cell biology; Transcription factor; Endocrinology; Gene expression; Nuclear receptor; Gonadotropin-releasing hormone; Gene; Biochemistry; Genetics; Hormone; Luteinizing hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639388,0.0003830206,0.0002406307,0.0002858513,0.0001577198,0.0002774698,0.0001951054,0.0001342771,0.001782675],"category_scores_gemma":[0.0001252473,0.0002002856,0.0003213226,0.0002031533,0.0001817044,0.0001136319,0.0001808821,0.000325056,0.001035395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002493402,"about_ca_system_score_gemma":0.0002730578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000727655,"about_ca_topic_score_gemma":0.0008021432,"domain_scores_codex":[0.9998778,0.00002074136,0.00001202338,0.00002604712,0.0000328952,0.00003039907],"domain_scores_gemma":[0.9999232,0.00001485893,0.00002177086,0.000009887161,0.00001147128,0.00001877564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006927873,0.00002105427,0.0001446456,0.00003788556,0.000003771956,0.00004961915,0.00001699433,0.00002167202,0.998863,0.00005572295,0.00002978119,0.0006864478],"study_design_scores_gemma":[0.00009730787,0.0002571186,0.01705394,0.00001702741,0.00002101374,0.0007027644,0.00005753431,0.002291306,0.9730724,0.0001082037,0.006313132,0.00000817094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869403,0.005025358,0.004698961,0.0001392196,0.00005571858,0.00005424437,0.0006551684,0.000132284,0.002298654],"genre_scores_gemma":[0.9833982,0.003463557,0.00397847,0.00009908132,0.00003137819,0.0001022007,0.0023594,0.00002939149,0.006538254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001782675,"threshold_uncertainty_score":0.005963683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004690607670135373,"score_gpt":0.2288237082808867,"score_spread":0.2241331006107513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}