{"id":"W2002001081","doi":"10.1016/s0197-4580(04)81755-x","title":"P4-197 Oxidative stress potentiates BACE1 gene expression and Aβ generation","year":2004,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Oxidative stress; Senile plaques; Amyloid precursor protein; Pathogenesis; Molecular biology; Green fluorescent protein; Amyloid precursor protein secretase; Downregulation and upregulation; Biology; Gene; BACE1-AS; Chemistry; Alzheimer's disease; Cell biology; Biochemistry; Medicine; Immunology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720486,0.0005343594,0.0005094828,0.0005730155,0.000443943,0.0004786717,0.000346704,0.0006118309,0.006819125],"category_scores_gemma":[0.0003875853,0.0003572431,0.0005086867,0.0002828618,0.0006212821,0.0003737425,0.0003813883,0.001122585,0.0009677163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003845209,"about_ca_system_score_gemma":0.0005545917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00215569,"about_ca_topic_score_gemma":0.001733717,"domain_scores_codex":[0.9997833,0.00003739688,0.00001647225,0.00003194347,0.00003344902,0.00009741972],"domain_scores_gemma":[0.9998149,0.00004728721,0.00003087897,0.00002451357,0.00001931317,0.00006317304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004694353,0.0005417798,0.0004877851,0.00005267996,0.00002885693,0.0004311385,0.00002857508,0.00006263243,0.9906154,0.0001750743,0.0002584193,0.002623464],"study_design_scores_gemma":[0.0001947229,0.002646337,0.008561214,0.0000092174,0.0000399716,0.0007089932,0.0001540685,0.0003192839,0.9848017,0.0004354768,0.00211816,0.00001091061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994675,0.0007024868,0.001168687,0.0003393297,0.0001283831,0.00004210261,0.0004117689,0.00005709671,0.002474982],"genre_scores_gemma":[0.989525,0.0007605876,0.001168242,0.0001881656,0.0000870492,0.0000827885,0.0009002614,0.00003070463,0.00725717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006819125,"threshold_uncertainty_score":0.02281225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745856345022933,"score_gpt":0.2984706329601342,"score_spread":0.2710120695099048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}