{"id":"W2002025697","doi":"10.1161/circulationaha.111.040337","title":"Wnt Signaling Mediates Pathological Vascular Growth in Proliferative Retinopathy","year":2011,"lang":"en","type":"article","venue":"Circulation","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Eye Institute; American Heart Association; Canadian Institutes of Health Research; Manton Center for Orphan Disease Research, Boston Children's Hospital; National Institutes of Health; Alcon Research Institute; Science Foundation Ireland; Charles H. Hood Foundation; V. Kann Rasmussen Foundation; Deutsche Forschungsgemeinschaft; Juvenile Diabetes Research Foundation International; Research to Prevent Blindness; Ögonfonden","keywords":"Wnt signaling pathway; LRP5; Neovascularization; Retinal; Retinopathy; Angiogenesis; Medicine; Cancer research; Frizzled; Pathology; Signal transduction; Cell biology; Biology; Endocrinology; Ophthalmology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001846597,0.0001002907,0.0001326408,0.00008039517,0.0001125408,0.00001527665,0.00006823277,0.00007144954,0.00007128724],"category_scores_gemma":[0.0005673917,0.00008094274,0.00004322752,0.0002533689,0.00007602474,0.0001535328,0.00002851761,0.0001265233,0.00002634214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002435011,"about_ca_system_score_gemma":0.000012023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007304052,"about_ca_topic_score_gemma":0.000001760583,"domain_scores_codex":[0.9990206,0.0001518839,0.0001929153,0.0003066402,0.0001720849,0.000155929],"domain_scores_gemma":[0.9996954,0.00006936054,0.00006452254,0.00008638585,0.00004832145,0.000036056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000576992,0.00007560501,0.6556828,0.00002090426,0.000007571844,0.000066549,0.01382343,0.00008299966,0.306764,0.02230788,0.00001741377,0.00109317],"study_design_scores_gemma":[0.000319228,0.00004010044,0.8099771,0.00001112057,0.00001079084,0.00001108774,0.0001994165,0.0003044281,0.1667709,0.02217948,0.00002292977,0.0001533654],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950594,0.00006141037,0.001832045,0.00004473676,0.000267138,0.0001964922,0.000001580567,0.00006952749,0.002467667],"genre_scores_gemma":[0.9993818,0.00001447239,0.0001878504,0.0002911796,0.00007728671,0.00003428906,0.000002029659,0.000007249746,0.000003779809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1542943,"threshold_uncertainty_score":0.3300749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06158830336030276,"score_gpt":0.2423939184310004,"score_spread":0.1808056150706976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}