{"id":"W2002025697","doi":"10.1161/circulationaha.111.040337","title":"Wnt Signaling Mediates Pathological Vascular Growth in Proliferative Retinopathy","year":2011,"lang":"en","type":"article","venue":"Circulation","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Eye Institute; American Heart Association; Canadian Institutes of Health Research; Manton Center for Orphan Disease Research, Boston Children's Hospital; National Institutes of Health; Alcon Research Institute; Science Foundation Ireland; Charles H. Hood Foundation; V. Kann Rasmussen Foundation; Deutsche Forschungsgemeinschaft; Juvenile Diabetes Research Foundation International; Research to Prevent Blindness; Ögonfonden","keywords":"Wnt signaling pathway; LRP5; Neovascularization; Retinal; Retinopathy; Angiogenesis; Medicine; Cancer research; Frizzled; Pathology; Signal transduction; Cell biology; Biology; Endocrinology; Ophthalmology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991433,0.0003604907,0.0001366694,0.0002246534,0.0001911202,0.0003505163,0.0001622675,0.000312648,0.00107262],"category_scores_gemma":[0.0001934194,0.0001211969,0.0001719349,0.0001041336,0.0002882825,0.0002667756,0.0002179958,0.0003648929,0.0002229457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006706879,"about_ca_system_score_gemma":0.0003123781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009556627,"about_ca_topic_score_gemma":0.0012189,"domain_scores_codex":[0.9998711,0.00002925054,0.000009560704,0.00001832985,0.00003594626,0.00003574934],"domain_scores_gemma":[0.9998938,0.00001267706,0.00004302449,0.000006432423,0.00001379677,0.00003025264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007437749,0.00005605384,0.002755559,0.0003179048,0.00002051184,0.0006414367,0.00006643139,0.0001928893,0.9865567,0.001944463,0.0003165344,0.006387688],"study_design_scores_gemma":[0.0001554699,0.000848711,0.05060915,0.0001213613,0.0001326768,0.002780189,0.0002003842,0.00276895,0.9222302,0.001633341,0.01850407,0.0000154656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689943,0.01941005,0.004064246,0.0003951221,0.00004400717,0.00004180417,0.000246828,0.0000777836,0.006725892],"genre_scores_gemma":[0.9923585,0.004345021,0.0009383054,0.00006391291,0.00001200508,0.00002184384,0.0002234174,0.000006723715,0.002030405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107262,"threshold_uncertainty_score":0.004866183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06158830336030276,"score_gpt":0.2423939184310004,"score_spread":0.1808056150706976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}