{"id":"W2002036002","doi":"10.1002/cmdc.201100199","title":"Bis[3,5‐bis(benzylidene)‐4‐oxo‐1‐piperidinyl]amides: A Novel Class of Potent Cytotoxins","year":2011,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Cytotoxicity; Chemistry; Class (philosophy); Stereochemistry; Combinatorial chemistry; Biochemistry; In vitro; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000237879,0.0003731599,0.0005944488,0.00005014766,0.00007993563,0.00001974613,0.0005798305,0.0004248563,0.002113424],"category_scores_gemma":[0.0004692582,0.0002857931,0.000360236,0.0001914354,0.0002805018,0.0001140498,0.0002436595,0.0003073596,0.0000461102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001116175,"about_ca_system_score_gemma":0.0000801178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001333103,"about_ca_topic_score_gemma":0.0000145187,"domain_scores_codex":[0.9980116,0.00001637693,0.0005189192,0.0005930947,0.0003237065,0.0005362976],"domain_scores_gemma":[0.9984134,0.0002388555,0.0003086672,0.0006855121,0.0001244777,0.0002290703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009959914,0.0009765724,0.002351562,0.0001407662,0.00009116366,0.00001091821,0.0001891199,4.553299e-7,0.9905218,0.0004123766,0.0003026735,0.004902991],"study_design_scores_gemma":[0.0005014588,0.00005625691,0.002449956,0.00008921838,0.00004653262,0.00001631641,0.0003870956,0.00005418655,0.9901596,0.0001545751,0.005703729,0.0003810232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8875824,0.0001644007,0.0001330445,0.0001227486,0.00008548694,0.00009069306,0.00007479879,0.0001451135,0.1116013],"genre_scores_gemma":[0.996731,0.00005213088,0.001407432,0.000147152,0.0002153772,0.00005059751,0.00001995382,0.00003859486,0.0013378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1102635,"threshold_uncertainty_score":0.9999594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08282666754708996,"score_gpt":0.2352228739647625,"score_spread":0.1523962064176725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}