{"id":"W2002036002","doi":"10.1002/cmdc.201100199","title":"Bis[3,5‐bis(benzylidene)‐4‐oxo‐1‐piperidinyl]amides: A Novel Class of Potent Cytotoxins","year":2011,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Cytotoxicity; Chemistry; Class (philosophy); Stereochemistry; Combinatorial chemistry; Biochemistry; In vitro; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275561,0.0002756129,0.000143485,0.0001736254,0.00009922432,0.0001662614,0.0001671146,0.0001200272,0.001103118],"category_scores_gemma":[0.00008261312,0.00008844154,0.00007904256,0.0001154675,0.0001316428,0.0002440641,0.0001496559,0.0002735028,0.0003226087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001426117,"about_ca_system_score_gemma":0.0001401388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008067777,"about_ca_topic_score_gemma":0.0002764237,"domain_scores_codex":[0.9999554,0.000009666674,0.000003196498,0.000009346006,0.00001059666,0.00001178902],"domain_scores_gemma":[0.9999453,0.000008930987,0.00001819515,0.000004364299,0.000004916202,0.0000183234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003674381,0.00009729234,0.0004897257,0.0001147821,0.000005877386,0.0001982762,0.00004937557,0.0006705887,0.9811025,0.0007098158,0.0001399904,0.01605432],"study_design_scores_gemma":[0.0002379506,0.006113923,0.006173036,0.00002103107,0.00004199718,0.001660847,0.00006149165,0.00214563,0.9639333,0.0003265883,0.01926294,0.00002140133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893587,0.002856759,0.004338706,0.0001386311,0.00002625367,0.00004437819,0.000198643,0.0001123102,0.002925587],"genre_scores_gemma":[0.9911386,0.002132832,0.004014373,0.00005361665,0.00002797333,0.00004412889,0.0002785321,0.00000902073,0.002300861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001103118,"threshold_uncertainty_score":0.003690362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08282666754708996,"score_gpt":0.2352228739647625,"score_spread":0.1523962064176725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}