{"id":"W2002037947","doi":"10.1089/104303404772679959","title":"Sustained Improvement of Muscle Function One Year After Full-Length Dystrophin Gene Transfer into <i>mdx</i> Mice by a Gutted Helper-Dependent Adenoviral Vector","year":2004,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; Montreal Neurological Institute and Hospital; McGill University","funders":"Merck","keywords":"Dystrophin; Duchenne muscular dystrophy; mdx mouse; Sarcolemma; Eccentric; Muscular dystrophy; Utrophin; Isometric exercise; Genetic enhancement; Viral vector; Biology; Internal medicine; Myocyte; Endocrinology; Medicine; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001060716,0.0002399715,0.0002187298,0.00004871566,0.0001046242,0.00001251564,0.0001875545,0.0001961374,0.0001778063],"category_scores_gemma":[0.00000304264,0.0002370095,0.0001405251,0.00007084941,0.0001118935,0.000008403349,0.00004998406,0.0001101632,0.000009413161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003880602,"about_ca_system_score_gemma":0.00006448429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001428975,"about_ca_topic_score_gemma":0.0001029685,"domain_scores_codex":[0.9987247,0.00005405432,0.0002952986,0.0004498924,0.0001674557,0.0003085805],"domain_scores_gemma":[0.9994094,0.000003142272,0.00006260646,0.0003604514,0.00008584516,0.00007856363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00227948,0.0004801454,0.0000297847,0.00002005385,0.0002088076,0.000001567001,0.000313507,0.00006322598,0.9948902,0.00005219709,0.0001167303,0.001544332],"study_design_scores_gemma":[0.004874662,0.003838331,0.002900294,0.000006785096,0.00003745927,0.000001023424,0.0001774093,0.000001264086,0.9868042,0.0005829,0.0004908451,0.0002847516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948067,0.001881906,0.002560018,0.0001319857,0.00009749416,0.0003994721,0.0000435933,0.00002333998,0.0000554728],"genre_scores_gemma":[0.9979344,0.0004555878,0.0001528339,0.000606636,0.0002136016,0.0001004411,0.0003560571,0.00004392573,0.0001365279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008085894,"threshold_uncertainty_score":0.9664967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006613967569036873,"score_gpt":0.2163690334967646,"score_spread":0.2097550659277277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}