{"id":"W2002037947","doi":"10.1089/104303404772679959","title":"Sustained Improvement of Muscle Function One Year After Full-Length Dystrophin Gene Transfer into <i>mdx</i> Mice by a Gutted Helper-Dependent Adenoviral Vector","year":2004,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; Montreal Neurological Institute and Hospital; McGill University","funders":"Merck","keywords":"Dystrophin; Duchenne muscular dystrophy; mdx mouse; Sarcolemma; Eccentric; Muscular dystrophy; Utrophin; Isometric exercise; Genetic enhancement; Viral vector; Biology; Internal medicine; Myocyte; Endocrinology; Medicine; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690912,0.0004357894,0.0005005067,0.0003355096,0.0001706429,0.0003623114,0.0002592818,0.0005144738,0.0009768999],"category_scores_gemma":[0.0001081752,0.0001243002,0.0002924108,0.0001462142,0.0002828797,0.0002666006,0.000197211,0.0009514821,0.0002904454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002359634,"about_ca_system_score_gemma":0.0002216597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004858972,"about_ca_topic_score_gemma":0.0008189151,"domain_scores_codex":[0.9998038,0.00001748128,0.00002028746,0.00006085551,0.00002851259,0.00006910007],"domain_scores_gemma":[0.999818,0.00002632844,0.00005618362,0.00002039534,0.0000152244,0.00006385386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001356316,0.0001190691,0.0001405498,0.00002004118,0.000003949173,0.00003609556,0.00001649959,0.00001900188,0.998281,0.0000292605,0.00002038621,0.001178549],"study_design_scores_gemma":[0.00005786556,0.003570334,0.008884061,0.0000126617,0.00003558859,0.0002556333,0.00004149478,0.000471512,0.9853804,0.0000335968,0.001248299,0.000008559852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960536,0.0007375696,0.001824383,0.00005474593,0.00004031226,0.00005285743,0.0003829672,0.0001451837,0.0007083252],"genre_scores_gemma":[0.9915773,0.000548053,0.00207981,0.00007701368,0.00002566779,0.00009643765,0.001199068,0.00003704469,0.004359685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009768999,"threshold_uncertainty_score":0.003268003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006613967569036873,"score_gpt":0.2163690334967646,"score_spread":0.2097550659277277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}