{"id":"W2002052963","doi":"10.1016/j.jalz.2012.05.1582","title":"P3‐357: Design, synthesis, and biological evaluation of novel fused‐ring systems to treat Alzheimer's disease","year":2012,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Butyrylcholinesterase; Combinatorial chemistry; Cholinesterase; Pharmacophore; Acetylcholinesterase; Antioxidant; Acridine; Chelation; Stereochemistry; Enzyme; Organic chemistry; Pharmacology; Aché","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340515,0.0002810452,0.0002195907,0.0002171962,0.0001255266,0.0002539205,0.0005227156,0.0002763547,0.003104538],"category_scores_gemma":[0.0001012669,0.0001198991,0.0002626514,0.0001852865,0.0001254357,0.0002319295,0.0001933947,0.0003627996,0.0008559059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002174606,"about_ca_system_score_gemma":0.000227847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000504949,"about_ca_topic_score_gemma":0.000590211,"domain_scores_codex":[0.9999484,0.000008120071,0.000003228161,0.00001201843,0.00001538729,0.00001293412],"domain_scores_gemma":[0.9999661,0.000003220384,0.000008177008,0.000003041949,0.000006856099,0.0000124604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006082421,0.0003571791,0.000222605,0.0005613864,0.00005852275,0.0003073888,0.00008336422,0.003172939,0.9377882,0.001977783,0.001040052,0.05382241],"study_design_scores_gemma":[0.0004802318,0.01426944,0.002719517,0.00009130126,0.0002278096,0.0007906044,0.00005349081,0.008139022,0.9190966,0.000705055,0.05336734,0.00005957227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501932,0.01063616,0.01964783,0.0003123745,0.0001053506,0.0005752288,0.001614547,0.0003514773,0.01656386],"genre_scores_gemma":[0.9740648,0.00461271,0.01502352,0.0002001325,0.00002538524,0.000185185,0.0008648729,0.00002766387,0.004995774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003104538,"threshold_uncertainty_score":0.01038569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1993517018444351,"score_gpt":0.3558825675532249,"score_spread":0.1565308657087899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}