{"id":"W2002066745","doi":"10.1016/j.ajpath.2011.05.001","title":"Prostaglandin E2 Produced by Entamoeba histolytica Signals via EP4 Receptor and Alters Claudin-4 to Increase Ion Permeability of Tight Junctions","year":2011,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Weizmann Institute of Science; Crohn's and Colitis Foundation of Canada","keywords":"Entamoeba histolytica; Tight junction; Prostaglandin E2; Claudin; Cell biology; Biology; Cryptosporidium parvum; Immunology; Microbiology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003333147,0.0001380223,0.0005046188,0.0002109506,0.00006846205,0.000003785514,0.00005327479,0.00004519072,0.0002385191],"category_scores_gemma":[0.0002174164,0.0001025597,0.00009792526,0.0002121892,0.0004412362,0.00007632585,0.00002737201,0.000176555,0.0000092185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001388412,"about_ca_system_score_gemma":0.00009076345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001457692,"about_ca_topic_score_gemma":0.000004289443,"domain_scores_codex":[0.9988998,0.0001793998,0.0003822904,0.0002110259,0.0001358667,0.0001916682],"domain_scores_gemma":[0.9988101,0.00005102438,0.0004348689,0.0002050917,0.0002394545,0.000259479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002609549,0.002245344,0.3891205,0.00005530831,0.0004002264,0.0003424268,0.003019904,6.698694e-7,0.5570844,0.00008854657,0.006147071,0.0388861],"study_design_scores_gemma":[0.01241154,0.09083293,0.550176,0.0004634833,0.002960681,0.02044072,0.003893797,0.00003606024,0.2883832,0.0006686696,0.02864157,0.001091359],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967658,0.0000973747,0.001281303,0.0009590281,0.0002103747,0.0002914044,0.00002113053,0.000009799181,0.0003637834],"genre_scores_gemma":[0.996437,0.00004675584,0.002916302,0.0002158679,0.00007091064,0.0000119508,0.000007165733,0.00001497841,0.0002791345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2687012,"threshold_uncertainty_score":0.4182262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294999157138963,"score_gpt":0.2577274206635001,"score_spread":0.2447774290921105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}