{"id":"W2002076929","doi":"10.1523/jneurosci.5495-10.2011","title":"Suppressor of Fused Is Required to Maintain the Multipotency of Neural Progenitor Cells in the Retina","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children; University of Ottawa; Ottawa Hospital","funders":"","keywords":"Biology; PAX6; Cell biology; Neural stem cell; Progenitor cell; Sonic hedgehog; SOX2; Transcription factor; Progenitor; Cell fate determination; Neurogenesis; Morphogen; Stem cell; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295431,0.000344205,0.0001766481,0.0003132776,0.0001880081,0.000272495,0.0002239205,0.0002573551,0.0009945456],"category_scores_gemma":[0.0001369474,0.0001812785,0.0001973253,0.0001035934,0.0002726242,0.0001561922,0.0002676716,0.0004708273,0.0003188091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389986,"about_ca_system_score_gemma":0.0002454472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005539149,"about_ca_topic_score_gemma":0.0009926831,"domain_scores_codex":[0.999872,0.00001486253,0.00001686614,0.00002374145,0.00004967993,0.00002272895],"domain_scores_gemma":[0.999817,0.00003328245,0.00005874358,0.00001948319,0.0000100507,0.00006156333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002241814,0.00000731975,0.0001321298,0.000007814821,0.000002046253,0.00006425707,0.000006534785,0.00003264303,0.9992628,0.00008579665,0.000007385839,0.0003689292],"study_design_scores_gemma":[0.00001255167,0.0001095167,0.007689443,0.00000421718,0.00001438095,0.0006917174,0.00002735114,0.001017687,0.9886652,0.00006480751,0.001698743,0.000004442139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961569,0.0005155005,0.002066854,0.00004524987,0.00001611438,0.000009842671,0.0002532662,0.00006376211,0.0008725197],"genre_scores_gemma":[0.9973062,0.0001806408,0.0007849853,0.00001772717,0.00000497793,0.000009140756,0.000350069,0.00002100884,0.001325226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009945456,"threshold_uncertainty_score":0.003327072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05123411115808101,"score_gpt":0.2781567178510704,"score_spread":0.2269226066929894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}