{"id":"W2002080354","doi":"10.1073/pnas.0702093104","title":"Single A326G mutation converts human CYP24A1 from 25-OH-D <sub>3</sub> -24-hydroxylase into -23-hydroxylase, generating 1α,25-(OH) <sub>2</sub> D <sub>3</sub> -26,23-lactone","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Hydroxylation; CYP24A1; Stereochemistry; Chemistry; Enzyme; Phosphofructokinase 2; Substrate (aquarium); Biochemistry; Biology; Gene; Calcitriol receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":["sts"],"category_scores_codex":[0.005651691,0.000704794,0.001031597,0.001160982,0.001860446,0.0001994595,0.001383306,0.0005133174,0.0000184421],"category_scores_gemma":[0.005207303,0.0005637195,0.0003935708,0.002855814,0.003299962,0.001716768,0.000844615,0.001239157,0.00005450976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006563818,"about_ca_system_score_gemma":0.000263103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004587373,"about_ca_topic_score_gemma":0.00002008466,"domain_scores_codex":[0.9901121,0.00008136906,0.001757745,0.001386022,0.005450995,0.001211722],"domain_scores_gemma":[0.9948446,0.001080551,0.001656704,0.0001083912,0.001822118,0.0004876023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001001034,0.000482319,0.002607987,0.000367375,0.0002096194,0.00000351371,0.00159477,0.0001524908,0.9859299,0.001879805,0.002381805,0.0042903],"study_design_scores_gemma":[0.001774172,0.0005285163,0.03431586,0.0007757566,0.0001660085,0.00006062529,0.001224545,0.00334791,0.9473009,0.009862573,0.0001174172,0.000525679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913766,0.0008828789,0.00003856824,0.004344927,0.0002020179,0.001179579,0.00008071143,0.000173321,0.001721441],"genre_scores_gemma":[0.9961476,0.0002237954,0.0013158,0.0009771218,0.001062197,0.00008080888,0.00002523898,0.00007807789,0.00008937663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03862898,"threshold_uncertainty_score":0.9996814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03906781962269619,"score_gpt":0.3149212854070017,"score_spread":0.2758534657843055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}