{"id":"W2002080354","doi":"10.1073/pnas.0702093104","title":"Single A326G mutation converts human CYP24A1 from 25-OH-D <sub>3</sub> -24-hydroxylase into -23-hydroxylase, generating 1α,25-(OH) <sub>2</sub> D <sub>3</sub> -26,23-lactone","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Hydroxylation; CYP24A1; Stereochemistry; Chemistry; Enzyme; Phosphofructokinase 2; Substrate (aquarium); Biochemistry; Biology; Gene; Calcitriol receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749332,0.0009193838,0.0004115243,0.0002512519,0.0002776085,0.0002641688,0.0003087137,0.0007209181,0.00303207],"category_scores_gemma":[0.0003115685,0.0002128573,0.0006998035,0.0002518453,0.0004087155,0.0001287555,0.0002912926,0.0007083282,0.001978953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002082263,"about_ca_system_score_gemma":0.0002764643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008150573,"about_ca_topic_score_gemma":0.0007828037,"domain_scores_codex":[0.9997987,0.00004925799,0.00002672696,0.00005245876,0.00005255009,0.00002031334],"domain_scores_gemma":[0.9997806,0.00003080373,0.00009223725,0.00002942903,0.00001568405,0.00005120237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004298601,0.0001301384,0.002010611,0.00009166041,0.00007549033,0.001454326,0.00005592252,0.0003966592,0.9858462,0.000479214,0.0004952514,0.008534689],"study_design_scores_gemma":[0.0002064776,0.001663755,0.01641154,0.00005461786,0.0001663364,0.01390822,0.00009010838,0.002685804,0.9376496,0.0004706704,0.02662244,0.00007054245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812462,0.002051718,0.009236825,0.0005511842,0.0004133139,0.0002307579,0.002193524,0.0005119478,0.003564605],"genre_scores_gemma":[0.9869981,0.001075613,0.006437634,0.0002121614,0.00006070352,0.00008351655,0.001641839,0.0001069129,0.003383653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00303207,"threshold_uncertainty_score":0.01014322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03906781962269619,"score_gpt":0.3149212854070017,"score_spread":0.2758534657843055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}