{"id":"W2002094413","doi":"10.1074/jbc.m109.032888","title":"Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":318,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; National Institutes of Health; American Diabetes Association","keywords":"Carnitine; Acetylcarnitine; Endocrinology; Internal medicine; Beta oxidation; Mitochondrion; Biology; Coenzyme A; Mitochondrial matrix; Carbohydrate metabolism; Skeletal muscle; Metabolism; Biochemistry; Enzyme; Medicine; Reductase; Cytosol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988721,0.000521184,0.000466883,0.0003210822,0.0001864439,0.0002314751,0.0001693571,0.0003299661,0.000592912],"category_scores_gemma":[0.0002554678,0.0001687,0.0002181561,0.0001761355,0.0003520779,0.0002757638,0.0003760278,0.0002809046,0.0001517256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002322017,"about_ca_system_score_gemma":0.0002360156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004807388,"about_ca_topic_score_gemma":0.0005987295,"domain_scores_codex":[0.9998969,0.00001336807,0.00002173137,0.00003381927,0.0000154028,0.00001881574],"domain_scores_gemma":[0.9997826,0.00001417502,0.0001039923,0.00002959424,0.00002054358,0.00004904775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007389048,0.00003519129,0.00988574,0.0001350856,0.00005152858,0.001073687,0.00009808555,0.0001290625,0.979179,0.0001966194,0.000103,0.008374078],"study_design_scores_gemma":[0.0001014776,0.004768826,0.5083609,0.0001110082,0.0003965954,0.01940347,0.0007015255,0.002178787,0.4489135,0.001710512,0.01329004,0.00006339286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912252,0.006071613,0.001830175,0.00009488239,0.00003396529,0.000009161464,0.0001348134,0.00006871806,0.0005315876],"genre_scores_gemma":[0.9955072,0.002656213,0.0008321918,0.00006942763,0.00001395118,0.00001508488,0.0002070612,0.0000114525,0.0006874028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000592912,"threshold_uncertainty_score":0.001983523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007331885039104461,"score_gpt":0.22282587346251,"score_spread":0.2154939884234055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}