{"id":"W2002100429","doi":"10.1002/cbic.201300547","title":"Mechanistic Insights from Substrate Preference in Unsaturated Glucuronyl Hydrolase","year":2013,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"British Columbia Knowledge Development Fund; Goddard Space Flight Center; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Hydrolase; Stereochemistry; Disaccharide; Substrate (aquarium); Moiety; Glycoside hydrolase; Enzyme; Aglycone; Transition state analog; Active site; Glycoside; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005441677,0.0001901681,0.0001495942,0.00006326775,0.00004816546,0.0000660339,0.0002711265,0.0002261189,0.0003949463],"category_scores_gemma":[0.0001192847,0.0001776464,0.00004866154,0.0002067548,0.00005870366,0.00001010159,0.0001071215,0.0001840042,0.0003936927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003016,"about_ca_system_score_gemma":0.00009885718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004580685,"about_ca_topic_score_gemma":0.0001822391,"domain_scores_codex":[0.9987562,0.00005132568,0.0002310842,0.0004763572,0.0001809011,0.0003041897],"domain_scores_gemma":[0.9992182,0.00001447303,0.00005693332,0.0004298323,0.000126303,0.000154301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004615291,0.00006958646,0.0003036601,0.00001010556,0.0000149848,0.00000639174,0.00003800508,0.000009437307,0.9981901,0.00009867809,0.0004721969,0.0007406667],"study_design_scores_gemma":[0.0007432034,0.00007884506,0.006134037,0.00001759998,0.000003551273,0.000002092765,0.00005143426,0.0009506411,0.9892004,0.001019365,0.001580141,0.0002186528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950762,0.0004813681,0.0001707863,0.0001052997,0.00005899257,0.0003874768,0.0000125193,0.00002306242,0.003684289],"genre_scores_gemma":[0.9975585,0.00005887702,0.0002504756,0.0001357527,0.00008432347,0.0001114229,0.0004833718,0.00002265314,0.001294672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008989698,"threshold_uncertainty_score":0.7244212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685184678470046,"score_gpt":0.2300289590053644,"score_spread":0.213177112220664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}