{"id":"W2002108236","doi":"10.1160/th09-04-0237","title":"HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions","year":2009,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Thrombin; Prothrombinase; Thromboplastin; Chemistry; Coagulation; Partial thromboplastin time; Aptamer; Prothrombin time; Pharmacology; Internal medicine; Biochemistry; Molecular biology; Biophysics; Medicine; Biology; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001419848,0.0003731133,0.0003177559,0.0002243011,0.0001100079,0.0002351248,0.0003244714,0.0004565267,0.00131192],"category_scores_gemma":[0.0001664674,0.0001594752,0.0002230205,0.0001222814,0.0002483312,0.0001740627,0.0001483045,0.0005184435,0.0003642633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000323533,"about_ca_system_score_gemma":0.0001814302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004278659,"about_ca_topic_score_gemma":0.0005489379,"domain_scores_codex":[0.9998786,0.00001661636,0.000009426186,0.00002964821,0.00003225636,0.0000333251],"domain_scores_gemma":[0.9998908,0.00003635662,0.0000326041,0.000007550331,0.000008295779,0.00002424875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001172615,0.00004586966,0.0001305105,0.0000377737,0.000007221602,0.00002398346,0.00001175346,0.0001080259,0.9965095,0.0000783933,0.00004106228,0.002888718],"study_design_scores_gemma":[0.00002937993,0.0009526977,0.001326369,0.000002559043,0.00001373814,0.0002281114,0.000008140381,0.0004516891,0.9953789,0.00002915274,0.001574624,0.00000460607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887522,0.005110291,0.004364428,0.0001096235,0.00004590334,0.00005774417,0.0001838694,0.0001290089,0.001247083],"genre_scores_gemma":[0.9917167,0.001300493,0.003921677,0.00009538308,0.00001774025,0.00003724438,0.0003979647,0.00001281698,0.002500055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00131192,"threshold_uncertainty_score":0.004388809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07068721468267684,"score_gpt":0.3145676417978087,"score_spread":0.2438804271151318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}