{"id":"W2002118607","doi":"10.1371/journal.pone.0001547","title":"Nucleoside Analogue Reverse Transcriptase Inhibitors Differentially Inhibit Human LINE-1 Retrotransposition","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; University of California, San Francisco; National Institute of Allergy and Infectious Diseases; Pfizer; Ontario HIV Treatment Network; Canadian Foundation for AIDS Research; Ontario Innovation Trust; National Institutes of Health","keywords":"Retrotransposon; Stavudine; Reverse transcriptase; Zidovudine; Biology; Nevirapine; Nucleoside Reverse Transcriptase Inhibitor; Virology; Genetics; Genome; Gene; Human immunodeficiency virus (HIV); RNA; Transposable element; Viral load; Viral disease; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005305355,0.0001428338,0.0001996023,0.00001695075,0.0004580344,0.00002420472,0.0001320665,0.0001074168,0.0009099874],"category_scores_gemma":[0.00001321131,0.00006721271,0.0001189162,0.000257943,0.0000670543,0.00009942244,0.00001687551,0.0001414,0.00006313774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002197727,"about_ca_system_score_gemma":0.000006703456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002978053,"about_ca_topic_score_gemma":0.0008283911,"domain_scores_codex":[0.9988773,0.00005625707,0.0002632724,0.0002746367,0.000302831,0.0002257179],"domain_scores_gemma":[0.9996449,0.0000264467,0.00005999386,0.00006703738,0.00007272268,0.0001288815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001675081,0.001051922,0.008221121,0.00001067735,0.00004027596,0.00001475471,0.0001629943,0.000001046368,0.9898662,0.00008367225,0.0001598573,0.0003707233],"study_design_scores_gemma":[0.0007504807,0.001117482,0.4303826,0.0002156395,0.0002447021,0.00001523213,0.00006913157,0.00009751533,0.5647799,0.000935353,0.0008590078,0.0005329421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970813,0.00004195053,0.000005334562,0.001735781,0.00004048962,0.0002387677,0.0001782368,0.0001084952,0.000569671],"genre_scores_gemma":[0.9981265,0.00008352758,0.0002404558,0.0002314372,0.0004752982,0.00002017011,0.0004932925,0.000001784767,0.0003275182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4250863,"threshold_uncertainty_score":0.9963723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0588732514759765,"score_gpt":0.2011499463107992,"score_spread":0.1422766948348227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}