{"id":"W2002118607","doi":"10.1371/journal.pone.0001547","title":"Nucleoside Analogue Reverse Transcriptase Inhibitors Differentially Inhibit Human LINE-1 Retrotransposition","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; University of California, San Francisco; National Institute of Allergy and Infectious Diseases; Pfizer; Ontario HIV Treatment Network; Canadian Foundation for AIDS Research; Ontario Innovation Trust; National Institutes of Health","keywords":"Retrotransposon; Stavudine; Reverse transcriptase; Zidovudine; Biology; Nevirapine; Nucleoside Reverse Transcriptase Inhibitor; Virology; Genetics; Genome; Gene; Human immunodeficiency virus (HIV); RNA; Transposable element; Viral load; Viral disease; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702795,0.0003076574,0.0003218567,0.0002108628,0.00006786694,0.0002939485,0.0001897916,0.0002146535,0.002191678],"category_scores_gemma":[0.0003435703,0.0000767711,0.0001625767,0.0002035655,0.00009834029,0.0001260271,0.00006686914,0.0003776694,0.0003900476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001874927,"about_ca_system_score_gemma":0.0001355702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004378235,"about_ca_topic_score_gemma":0.0009119171,"domain_scores_codex":[0.9998474,0.00004893188,0.00001824267,0.00002216164,0.00003749584,0.00002574661],"domain_scores_gemma":[0.9997594,0.0001208156,0.00004803425,0.00001788273,0.00002747322,0.00002639963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001309124,0.0002833912,0.0008742351,0.0001458418,0.00004862555,0.00008140801,0.0000328729,0.0002908671,0.980979,0.0001200807,0.0001983176,0.01563618],"study_design_scores_gemma":[0.0002079823,0.006962131,0.006301208,0.00001810387,0.00009880726,0.0008072328,0.00002865234,0.001289633,0.9791195,0.00004938849,0.005108327,0.000009019669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825367,0.01185389,0.001200033,0.00007186389,0.00006356122,0.00007574692,0.0005640433,0.0000749005,0.003559191],"genre_scores_gemma":[0.9921889,0.003675557,0.001434595,0.000057045,0.0000329761,0.00003258576,0.0009010131,0.00001852425,0.001658693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002191678,"threshold_uncertainty_score":0.007331967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0588732514759765,"score_gpt":0.2011499463107992,"score_spread":0.1422766948348227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}